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Titolo:
Hepatocellular oxidative stress and initial graft injury in human liver transplantation
Autore:
Ardite, E; Ramos, C; Rimola, A; Grande, L; Fernadez-Checa, JC;
Indirizzi:
Univ Barcelona, CSIC, Hosp Clin, Inst Invest Biomed,Dept Med,Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 er Unit, E-08036 Barcelona, Spain Univ Barcelona, CSIC, Hosp Clin, Inst Invest Biomed,Dept Surg,Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 er Unit, E-08036 Barcelona, Spain
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 5, volume: 31, anno: 1999,
pagine: 921 - 927
SICI:
0168-8278(199911)31:5<921:HOSAIG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; PERFUSED-RAT-LIVER; REPERFUSION INJURY; REACTIVE OXYGEN; ISCHEMIA-REPERFUSION; LIPID-PEROXIDATION; MITOCHONDRIAL GLUTATHIONE; ENDOTHELIAL-CELLS; HEPATIC ISCHEMIA; XANTHINE-OXIDASE;
Keywords:
antioxidants; free radicals; glutathione; ischemia-reperfusion; mitochondria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fernadez-Checa, JC Univ Barcelona, CSIC, Hosp Clin, Inst Invest Biomed,Dept Med,Liver Unit, Villarroel 170, E-08036 Barcelona, Spain Univ Barcelona Villarroel 170 Barcelona Spain E-08036
Citazione:
E. Ardite et al., "Hepatocellular oxidative stress and initial graft injury in human liver transplantation", J HEPATOL, 31(5), 1999, pp. 921-927

Abstract

Background/Aims: The mechanisms underlying the initial graft dysfunction in liver transplantation are not completely understood, although much of theliver graft injury derives from the ischemia/reperfusion-induced oxidativestress, Thus, the purpose of our study was to determine the involvement ofoxidative stress in the initial graft dysfunction in human liver transplantation. Methods: Liver biopsies were taken at different times of the transplantation procedure, at the organ donor laparatomy (TI), before graft reperfusion (T2), and 5-60 min after graft reperfusion (T3), determining the levels of GSH, GSSG, as well as peroxides and malondialdehyde in liver homogenates. Results: Patients were graded into two groups depending on whether the peak serum alanine aminotransferases within the first 3 postoperative days were lower (group A, mild to moderate injury: 32 patients) or higher (group B,severe injury: 5 patients) than 2500 Un, The levels of GSH at time intervals T1-T3 were similar for groups A and B, with a trend to lower GSSG levelsin group B at T2 and T3 samples. This outcome was accompanied by unchangedlevels of malondialdehyde and hydrogen peroxide in the same samples in both groups of patients, No patient developed primary graft nonfunction, One-year cumulative survival was 81% and 60% in groups A and B, respectively (p>0.05),Conclusions: These findings indicate a lack of significant generation of reactive oxygen species and consequent oxidative stress as a major factor involved in the pathogenesis of the initial graft dysfunction in human liver transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:13:25