Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Projections of cochlear root neurons, sentinels of the rat auditory pathway
Autore:
Lopez, DE; Saldana, E; Nodal, FR; Merchan, MA; Warr, WB;
Indirizzi:
Univ Salamanca, Fac Med, Lab Neurobiol Audic, Dept Biol Celular & Patol, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 lar & Patol, Salamanca 37007, Spain Univ Salamanca, Inst Neurosci, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 st Neurosci, Salamanca 37007, Spain Boys Town Natl Res Hosp, Omaha, NE 68131 USA Boys Town Natl Res Hosp Omaha NE USA 68131 Res Hosp, Omaha, NE 68131 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 415, anno: 1999,
pagine: 160 - 174
SICI:
0021-9967(199912)415:2<160:POCRNS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN PERIAQUEDUCTAL GRAY; PONTINE RETICULAR-FORMATION; ACOUSTIC STARTLE RESPONSE; SUPERIOR COLLICULUS; BRAIN-STEM; ELECTRICAL-STIMULATION; HORSERADISH-PEROXIDASE; GIANT-NEURONS; INFERIOR COLLICULUS; FACIAL NUCLEUS;
Keywords:
acoustic startle reflex; biotinylated dextran amine (BDA); cochlear nucleus; escape responses; reticular formation; albino rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lopez, DE Univ Salamanca, Fac Med, Lab Neurobiol Audic, Dept Biol Celular & Patol, Alfonso X El Sabio S-N, Salamanca 37007, Spain Univ Salamanca Alfonso X El Sabio S-N Salamanca Spain 37007 ain
Citazione:
D.E. Lopez et al., "Projections of cochlear root neurons, sentinels of the rat auditory pathway", J COMP NEUR, 415(2), 1999, pp. 160-174

Abstract

In certain rodents, the root of the cochlear nerve contains a population of large neurons, known as cochlear root neurons (CRNs), an essential element of the primary acoustic startle pathway. To characterize the projections of the CRNs, we made stereotaxically guided, iontophoretic injections of biotinylated tracers into the cochlear nerve root of albino rats. CRN axons, which are remarkably thick, enter the trapezoid body, cross themidline, and ascend in the rostral aspect of the lateral lemniscus to reach the upper levels of the midbrain. As a group, CRN axons produce a characteristic pattern of profusely ramified collaterals that innervate specific brainstem regions. The main target of CRN axons is the contralateral pontinereticular formation, where collaterals terminate in the caudal pontine reticular nucleus (PnC) and, to a lesser degree, in the ventrolateral tegmental area, the oral pontine reticular nucleus, and the rostral and medial paralemniscal regions. Other targets of CRN axons include the lateral paragigantocellular nucleus of both sides, the ipsilateral facial motor nucleus and PnC, and the contralateral intercollicular tegmentum and superior colliculus. Notably, CRNs apparently do not innervate any of the nuclei of the auditory brainstem, as usually defined, even though their axons pass through or in close proximity to them. The fact that CRNs innervate several reticular and tectal structures that mediate auditory alerting and escape behaviors suggests that they are "early warning neurons," i.e., true sentinels of the auditory pathway. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:38:50