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Titolo:
Gender-related differences in pharmacokinetics and their clinical significance
Autore:
Tanaka, E;
Indirizzi:
Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
fascicolo: 5, volume: 24, anno: 1999,
pagine: 339 - 346
SICI:
0269-4727(199910)24:5<339:GDIPAT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE SPARTEINE METABOLISM; ORAL-CONTRACEPTIVE STEROIDS; SEX-RELATED DIFFERENCES; DRUG-METABOLISM; GENETIC-POLYMORPHISM; HUMAN LIVER; CYTOCHROMES P450; MENSTRUAL-CYCLE; THEOPHYLLINE PHARMACOKINETICS; MEPHENYTOIN HYDROXYLATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, E Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 araki 3058575, Japan
Citazione:
E. Tanaka, "Gender-related differences in pharmacokinetics and their clinical significance", J CLIN PH T, 24(5), 1999, pp. 339-346

Abstract

In this review I have attempted to summarize gender differences in pharmacokinetics involving the cytochrome F450 (CYP) isozymes of young and mature adults, excluding the effects of the menstrual cycle, use of oral contraceptives and pregnancy. Sex differences in drug metabolism and elimination aremainly related to steroid hormone levels. CYP3A4, responsible for the metabolism of over 50% of therapeutic drugs, exhibits higher activity in women than in men. Nonetheless, the absence of a sex difference has been reportedby some workers. The activity of several other CYP (CYP2C19, CYP2D6, CYP2E1) isozymes and the conjugation (glucuronidation) activity involved in drugmetabolism may be higher in men than in women. Drug metabolism in women isaffected by sex-specific factors (menopause, pregnancy and menstruation) in addition to the cigarette smoking, drug ingestion and alcohol consumptionthat are more commonly observed factors in men. Furthermore, they are affected by physiological factors such as drug absorption, protein binding and elimination. Thus, careful attention should be paid to the side-effects andtoxicity arising from sex differences in drug metabolism in clinical situations. Although there are specific ethical considerations regarding carrying out drug trials in women, the relationship between the side-effects and toxicity that may be influenced by hormones during drug metabolism and drug treatment needs further study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:31:16