Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Packed-column supercritical fluid chromatography for the purity analysis of clevidipine, a new dihydropyridine drug
Autore:
Gyllenhaal, O; Karlsson, A; Vessman, J;
Indirizzi:
AstraZeneca R&D Molndal, Dept Analyt Chem, S-43183 Molndal, Sweden AstraZeneca R&D Molndal Molndal Sweden S-43183 , S-43183 Molndal, Sweden
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1, volume: 862, anno: 1999,
pagine: 95 - 104
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOBILE PHASES; SEPARATION;
Keywords:
purity analysis; clevidipine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gyllenhaal, O AstraZeneca R&D Molndal, Dept Analyt Chem, S-43183 Molndal, Sweden AstraZeneca R&D Molndal Molndal Sweden S-43183 dal, Sweden
Citazione:
O. Gyllenhaal et al., "Packed-column supercritical fluid chromatography for the purity analysis of clevidipine, a new dihydropyridine drug", J CHROMAT A, 862(1), 1999, pp. 95-104

Abstract

In this paper we describe a packed column supercritical fluid chromatography method that can be used for the analysis of a new dihydropyridine substance. The method is based on methanol-modified carbon dioxide as the mobile phase and Hypersil bare silica as column support at a column temperature of50 degrees C and 150 bar as back pressure. Using an adjusted methanol gradient the most likely by-products can be separated and detected (240 nm) within 13 min. Occasionally the column needed treatment with 4 mM citric acid in the methanol modifier in order to give a narrow peak of an acidic analogue. The present method can detect analogues at the 0.1% (w/w) level. The precision at this level for one of the analogues was 5.9% RSD. This method shows a higher selectivity than a corresponding reversed-phase liquid chromatographic method. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:06:18