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Titolo:
Evidence of three-dimensional scroll waves with ribbon-shaped filament as a mechanism of ventricular tachycardia in the isolated rabbit heart
Autore:
Efimov, IR; Sidorov, V; Cheng, Y; Wollenzier, B;
Indirizzi:
Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ardiol, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 11, volume: 10, anno: 1999,
pagine: 1452 - 1462
SICI:
1045-3873(199911)10:11<1452:EOTSWW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLTAGE-SENSITIVE DYES; SPIRAL WAVES; CARDIAC FIBRILLATION; CHEMICAL ACTIVITY; CIRCUS MOVEMENT; HIGH-RESOLUTION; ATRIAL MUSCLE; INTACT HEARTS; REENTRANT; VORTICES;
Keywords:
ventricular arrhythmia; sudden cardiac death; scroll wave; fluorescent dye; optical mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Efimov, IR Cleveland Clin Fdn, Dept Cardiol, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 5 USA
Citazione:
I.R. Efimov et al., "Evidence of three-dimensional scroll waves with ribbon-shaped filament as a mechanism of ventricular tachycardia in the isolated rabbit heart", J CARD ELEC, 10(11), 1999, pp. 1452-1462

Abstract

Rotating vortices have been observed in excitable media of different nature, Vortices may sustain life or kill in different species, by underlining morphogenesis in Dictiostelium discoideum during starvation, or arrhythmias during sudden cardiac death in mammals, Investigation of vortices in the heart has been limited by two-dimensional experimental techniques. In contrast, three-dimensional (3D) Belousov-Zhabotinsky excitable medium and mathematical models have been shown to sustain scroll-shaped waves, The heart is a3D structure; therefore, scroll waves may underlie cardiac arrhythmias,Methods and Results: We used potentiometric dye and optical mapping techniques to study vortices during ventricular arrhpthmias, The core of all observed vortices were linearly shaped and greater than or equal to 9 mm (48 episodes, six hearts). As shown by Allessie et al, in the rabbit atrium, ventricular signals recorded within 1 to 2 mm from the line of block were dual humped, suggesting there is electrotonic interaction across the line of block. We hypothesized that the line of block represents epicardial intersection of ribbon-shaped filaments, which in some cases may be oriented under anangle or parallel to the epicardium. In la episodes we observed dual-humped optical recordings at one side of the line of block at a distance up to 12 mm, The two humps may represent the signatures of two activation wavefronts propagating above and below the filament, which in this area is close tothe epicardial surface. The activation sequence of the two waves is consistent with the idea of a scroll wave with ribbon-like filament. Conclusion: Our data pro,ide new insights into the shape and dynamics of the filament of the 3D scroll wave, which underlies the mechanism of ventricular tachycardia in the rabbit heart. The filament of the scroll wave mag be ribbon shaped, with a significant width greater than or equal to 9 mm anda thickness of 1 to 2 mm, No evidence of fully excitable cells in the coreof vortex was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:18:45