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Titolo:
Cytoreductive surgery in advanced endocrine tumours of the pancreas
Autore:
Pederzoli, P; Falconi, M; Bonora, A; Salvia, R; Sartori, N; Contro, C; Marcucci, S; Bassi, C;
Indirizzi:
Univ Verona, Policlin Borgo Roma, Endocrine Surg Serv, Dept Surg Sci, I-37134 Verona, Italy Univ Verona Verona Italy I-37134 v, Dept Surg Sci, I-37134 Verona, Italy
Titolo Testata:
ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
, volume: 31, anno: 1999, supplemento:, 2
pagine: S207 - S212
SICI:
1125-8055(199910)31:<S207:CSIAET>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ARTERIAL CHEMOEMBOLIZATION; NEUROENDOCRINE TUMORS; CARCINOID-TUMORS; MANAGEMENT;
Keywords:
cytoreductive surgery; metastatic endocrine tumours; pancreatic endocrine tumours;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Pederzoli, P Univ Verona, Policlin Borgo Roma, Endocrine Surg Serv, Dept Surg Sci, I-37134 Verona, Italy Univ Verona Verona Italy I-37134 Sci, I-37134 Verona, Italy
Citazione:
P. Pederzoli et al., "Cytoreductive surgery in advanced endocrine tumours of the pancreas", ITAL J GAST, 31, 1999, pp. S207-S212

Abstract

Surgery still plays an important role evert in advanced endocrine tumours of the pancreas, owing to their biological behaviour. Sometimes it is possible to attempt a radical approach, but more often only cytoreduction is feasible. lit fact, when the malignancy is not completely resectable on account of vessel involvement or extensive liver metastases, surgical reduction of the tumour burden (debulking) can be proposed, aimed at improving the clinical conditions and survival of these patients. Forty-one patients suffering from advanced endocrine tumour of the pancreas were observed from 1985 to 1996 in 13 patients, the disease was locally advanced as far as concerns lymph node metastases and/or vessel involvement, while the other 28 patients presented liver metastases. In the former group, we performed 6 radical resections, in the latter we submitted 2 patients to radical resection and 22 patients to cytoreductive surgery, with complete removal of the pancreatic malignancy. The overall survival of the resected patients was 87% (7/8). Three patients (37.5%) are alive and free of disease, while the other 4 have subsequently developed liver metastases. One patient died with hepatic recurrence. Half the patients (6/12) undergoing cytoreductive surgery are alive, 3 with stable and 3 with progressive disease. The other 6 patients havedied due to liver progression of the disease. As data in the literature concerning the role of debulking as regards the survival are conflicting, we have modified our surgical approach in patients with advanced disease. We perform cytoreductive surgery whenever complete removal of the pancreatic tumour is feasible. The rationale of this approach is to leave only a liver with residual disease, with a view to giving targeted adjuvant treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:49:41