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Titolo:
Pretreatment factors predict overall survival for patients with low-grade glioma: A recursive partitioning analysis
Autore:
Bauman, G; Lote, K; Larson, D; Stalpers, L; Leighton, C; Fisher, B; Wara, W; MacDonald, D; Stitt, L; Cairncross, JG;
Indirizzi:
London Reg Canc Ctr, Dept Radiat Oncol, London, ON N6A 4L6, Canada London Reg Canc Ctr London ON Canada N6A 4L6 , London, ON N6A 4L6, Canada Univ Western Ontario, Dept Oncol, London, ON, Canada Univ Western OntarioLondon ON Canada io, Dept Oncol, London, ON, Canada Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada Univ Western Ontario London ON Canada miol & Biostat, London, ON, Canada Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada Univ Western Ontario London ON Canada lin Neurol Sci, London, ON, Canada Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA col, San Francisco, CA USA Amsterdam Med Ctr, Dept Radiat Oncol, Amsterdam, Netherlands Amsterdam MedCtr Amsterdam Netherlands t Oncol, Amsterdam, Netherlands Norwegian Radium Hosp, Dept Oncol, Oslo, Norway Norwegian Radium Hosp Oslo Norway Radium Hosp, Dept Oncol, Oslo, Norway
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 4, volume: 45, anno: 1999,
pagine: 923 - 929
SICI:
0360-3016(19991101)45:4<923:PFPOSF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; PROGNOSTIC FACTORS; CEREBRAL ASTROCYTOMAS; SUPRATENTORIAL ASTROCYTOMAS; COGNITIVE FUNCTIONS; ADULTS; RADIOTHERAPY; MANAGEMENT; OLIGODENDROGLIOMAS; RADIOSURGERY;
Keywords:
low-grade glioma; astrocytoma; oligodendroglioma; mixed oligoastrocytoma; prognostic factors; radiotherapy; outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bauman, G London Reg Canc Ctr, Dept Radiat Oncol, 790 Commissioners Rd E, London, ONN6A 4L6, Canada London Reg Canc Ctr 790 Commissioners Rd E LondonON Canada N6A 4L6
Citazione:
G. Bauman et al., "Pretreatment factors predict overall survival for patients with low-grade glioma: A recursive partitioning analysis", INT J RAD O, 45(4), 1999, pp. 923-929

Abstract

Purpose: Three databases were pooled and analyzed to determine which groupings of prognostic factors best predicted overall survival for patients with low-grade gliomas treated with surgery and immediate or delayed radiotherapy. Methods and Materials: Databases of patients with low-grade gliomas compiled at the London Regional Cancer Centre (LRCC), the Norwegian Radium Hospital (NRH), and the University of California, San Francisco (UCSF) were merged. Inclusion criteria for the pooled analysis included: age greater than orequal to 18 years and histologically confirmed low-grade (World Health Organization Grade II) supratentorial fibrillary astrocytoma, oligodendroglioma or mixed oligoastrocytoma. Factors analyzed for prognostic significance included: age at diagnosis, gender, seizures at presentation, presence of enhancement on computed tomography (CT) or magnetic resonance imaging (MRI), Karnofsky Performance Status (KPS) at diagnosis, histology, extent of surgical resection, timing of radiotherapy, and treating institution. Univariateand multivariate analysis of overall survival for these factors was performed. Recursive partitioning was performed to generate prognostic groups using these factors. Results: From the combined databases, 401 patients were eligible for analysis. Median survival for the entire group,vas 95 months/7.9 years. On univariate analysis age 18-40, presence of seizures at presentation, KPS greaterthan or equal to 70, treating institution, and absence of contrast enhancement were associated with improved overall survival. On multivariate analysis, these factors remained independent predictors of improved overall survival. Recursive partitioning analysis yielded four prognostic groups with statistically different median survivals (MS): Group I (n = 41: KPS < 70, age> 40) MS 12 months; Group II (n = 34: KPS greater than or equal to 70, age> 40, enhancement present) MS 46 months; Group III (n = 138: KPS < 70, age18-40 or KPS greater than or equal to 70 age > 40, no enhancement) MS 87 months; Group IV (n = 188: KPS greater than or equal to 70, age 18-40) MS 128 months. Conclusion: Clusters of pretreatment prognostic factors described subgroups of low-grade glioma patients with divergent overall survivals. Consideration of these prognostic subgroups may be important when considering timing of interventions for these patients and in the stratification of patients for clinical trials. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:29:58