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Titolo:
Elastic pressure-volume curves of the respiratory system reveal a high tendency to lung collapse in young pigs
Autore:
Liu, JM; De Robertis, E; Blomquist, S; Dahm, PL; Svantesson, C; Jonson, B;
Indirizzi:
Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 pt Clin Physiol, S-22185 Lund, Sweden Univ Lund Hosp, Dept Anaesthesia & Intens Care, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 a & Intens Care, S-22185 Lund, Sweden Univ Naples Federico II, Dept Anaesthesia & Intens Care, Naples, Italy Univ Naples Federico II Naples Italy hesia & Intens Care, Naples, Italy
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 10, volume: 25, anno: 1999,
pagine: 1140 - 1146
SICI:
0342-4642(199910)25:10<1140:EPCOTR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEST-WALL MECHANICS; DISTRESS SYNDROME; TIDAL VOLUME; VENTILATION; RECRUITMENT; ANESTHESIA; PULMONARY; HUMANS; CATS; ARDS;
Keywords:
animal; porcine; mechanics; compliance; elastic recoil; recruitment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Jonson, B Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 ysiol, S-22185 Lund, Sweden
Citazione:
J.M. Liu et al., "Elastic pressure-volume curves of the respiratory system reveal a high tendency to lung collapse in young pigs", INTEN CAR M, 25(10), 1999, pp. 1140-1146

Abstract

Objective: To study pressure-volume (P/V) curves over a wide pressure and volume range in pigs. Design: Dynamic and static P/V curves (P-dyn/V and P-st/V) and compliance of the respiratory system were studied. The effects of recruitment, positive end-expiratory pressure (PEEP) and body position were analysed. Setting: Research animal laboratory. Materials: Seven anaesthetised, paralysed and ventilated healthy pigs of 21 kg. Measurements: PN curves up to a pressure of about 40 cmH(2)O were recordedwith a computer-controlled ventilator. P-st/V curves were obtained with the static occlusion method and P-dyn/V curves during an insufflation at a low, constant flow rate. Results: P-dyn/V recording showed a complex pattern. During the insufflation compliance increased, fell, increased and fell again. A 2nd P-dyn/V recording immediately following the 1st one was displaced towards higher volumes and showed only one maximum of compliance. The difference between the twocurves reflected: (1) lung collapse during a period of 5 min of ventilation at zero end-expiratory pressure (ZEEP) following a recruitment manoeuvre,(2) recruitment during the measurement of the 1st P-dyn/V curve. These observations were similar in the supine and in the left lateral position. After ventilation at PEEP, 4 cmH(2)O, the signs of collapse and recruitment were reduced. It was confirmed that PEEP offers a partial protection against collapse. P-st/V curves showed higher volumes and higher compliance values compared to P-dyn/V curves. This reflects the influence of viscoelastance onP-dyn/V curves. Conclusion: The study demonstrates a particularly strong tendency to lung collapse in pigs.

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Documento generato il 01/12/20 alle ore 08:05:37