Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vaccination against helminth parasites - the ultimate challenge for vaccinologists?
Autore:
Maizels, RM; Holland, MJ; Falcone, FH; Zang, XX; Yazdanbakhsh, M;
Indirizzi:
Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 3JT Midlothian, Scotland Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands Leiden Univ Leiden Netherlands Ctr, Dept Parasitol, Leiden, Netherlands
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 171, anno: 1999,
pagine: 125 - 147
SICI:
0105-2896(199910)171:<125:VAHP-T>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LYMPHATIC FILARIASIS; INTESTINAL NEMATODE INFECTION; SCHISTOSOMA-MANSONI INFECTION; ONCHOCERCA-VOLVULUS INFECTION; PROTECTIVE IMMUNE-RESPONSES; DEFINED RECOMBINANT ANTIGEN; TRIOSE-PHOSPHATE ISOMERASE; BRUGIA-MALAYI INFECTION; ACID-BINDING PROTEIN; ADULT WORM ANTIGENS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
236
Recensione:
Indirizzi per estratti:
Indirizzo: Maizels, RM Univ Edinburgh, Inst Cell Anim & Populat Biol, W Mains Rd, Edinburgh EH9 3JT, Midlothian, Scotland Univ Edinburgh W Mains Rd Edinburgh Midlothian Scotland EH9 3JT
Citazione:
R.M. Maizels et al., "Vaccination against helminth parasites - the ultimate challenge for vaccinologists?", IMMUNOL REV, 171, 1999, pp. 125-147

Abstract

Helminths are multicellular pathogens which infect vast numbers of human and animal hosts, causing widspread chronic disease and morbidity. Vaccination against these parasites requires more than identification of effective target antigens, because without understanding the immunology of the host-parasite relationship, ineffective immune mechanisms may be invoked, and there is a danger of amplifying immunopathogenic responses. The fundamental features of the immune response to helminths are therefore summarised in the context of vaccines to helminth parasites. The contention between type-1 andtype-2 responses is a central issue in helminth infections, which bias theimmune system strongly to the type-2 pathway. Evidence from both human andexperimental animal infections indicates that both lineages contribute to immunity in differing circumstances, and that a balanced response leads to the most favourable outcome. A diversity of immune mechanisms can be brought to bear on various helminth species, ranging from antibody-independent macrophages, antibody-dependent granulocyte killing, and non-lymphoid actions, particularly in the gut. This diversity is highlighted by analysis of rodent infections, particularly in comparisons of cytokine-depleted and gene-targeted animals. This knowledge of protective mechanisms needs to be combined with a careful choice of parasite antigens for vaccines. Many existing candidates have been selected with host antibodies, rather than T-cell responses, and include a preponderance of highly conserved proteins with similarities to mammalian or invertebrate antigens. Advantage has yet to be taken of parasite genome projects, or of directed searches for novel, parasite-specific antigens and targets expressed only by infective stages and not mature forms which may generate immunopathology. With advances under way in parasite genomics and new vaccine delivery systems offering more rapid assessment and development, there are now excellent opportunities for new antihelminth vaccines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 08:53:53