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Titolo:
Sex steroids, insulin, and arterial stiffness in women and men
Autore:
Giltay, EJ; Lambert, J; Gooren, LJG; Elbers, JMH; Steyn, M; Stehouwer, CDA;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Internal Med, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Res Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Inst Cardiovasc Res, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 34, anno: 1999,
parte:, 1
pagine: 590 - 597
SICI:
0194-911X(199910)34:4<590:SSIAAS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HORMONE REPLACEMENT THERAPY; SMOOTH-MUSCLE CELLS; POSTMENOPAUSAL WOMEN; AORTIC DISTENSIBILITY; DIABETES-MELLITUS; ESTROGEN-RECEPTOR; FASTING GLUCOSE; BLOOD-PRESSURE; HEMODYNAMICS;
Keywords:
arteries; insulin; gender; estrogen; testosterone; coefficient, distensibility; coefficient, compliance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Free Univ Amsterdam Hosp, Dept Internal Med, POB 7057, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "Sex steroids, insulin, and arterial stiffness in women and men", HYPERTENSIO, 34(4), 1999, pp. 590-597

Abstract

Arterial stiffness may be influenced by sex steroids and insulin; the association with fasting insulin level may be stronger in women than in men. Therefore, we analyzed the effects of sex steroid administration on (1) arterial stiffness and (2) the relationship between fasting insulin level and arterial stiffness. Twelve male-to-female transsexuals were treated with ethinyl estradiol and cyproterone acetate, and 18 female-to-male transsexuals were treated with testosterone esters, with assessments made at baseline andafter 4 and 12 months. Changes in distensibility and compliance coefficients (D and CC, respectively) of the common carotid artery, femoral artery (FA), and brachial artery (BA) were analyzed in relation to changes in fasting plasma levels of glucose, insulin, HDL-cholesterol, and triglycerides. After 4 months of estrogens and antiandrogens in men, significant reductions in the CC and DC of the FA (P=0.06 and P=0.4, respectively) and BA (P=0.04 and P=0.04, respectively) were observed. In women, testosterone, on average, did not affect DC or CC, but the changes in fasting insulin level were strongly negatively associated with changes in the CC and DC, especially in the FA and BA. These associations were significantly less strong in genetic men and were independent of age, mean arterial pressure, and glucose and lipid levels. This experimental study shows (1) that short-term administration of estrogens and antiandrogens increases FA and BA stiffness in men and (2) that the fasting insulin level is a stronger determinant of arterial stiffness in women than in men.

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Documento generato il 04/12/20 alle ore 22:26:18