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Titolo:
Comparison of human cervical mucus and artificial sperm penetration media
Autore:
Tang, S; Garrett, C; Baker, HWG;
Indirizzi:
Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, Carlton, Vic 3053, Australia Univ Melbourne Carlton Vic Australia 3053 l, Carlton, Vic 3053, Australia Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 11, volume: 14, anno: 1999,
pagine: 2812 - 2817
SICI:
0268-1161(199911)14:11<2812:COHCMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-COITAL TEST; HUMAN-SPERMATOZOA; POSTCOITAL TEST; IN-VITRO; PROGNOSTIC VALUE; CLINICAL-SIGNIFICANCE; ANTISPERM ANTIBODIES; POLYACRYLAMIDE-GEL; STRICT CRITERIA; MIGRATION TEST;
Keywords:
cervical mucus; mucus substitute; sperm autoimmunity; sperm motility; sperm-mucus penetration test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, HWG Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, Carlton, Vic 3053, Australia Univ Melbourne Carlton Vic Australia 3053 Vic 3053, Australia
Citazione:
S. Tang et al., "Comparison of human cervical mucus and artificial sperm penetration media", HUM REPR, 14(11), 1999, pp. 2812-2817

Abstract

The cervical mucus penetration tests aid research and determine the clinical importance of positive sperm antibody tests. Limited availability and variability of human cervical mucus have instigated the search for mucus substitutes for these tests. This study compares sperm migration in cervical mucus with that in artificial media including hyaluronate solution, egg whiteand albumin Tyrode solution. Results were quantified by measuring the migration distance (the maximum distance of capillary migration from a semen reservoir by spermatozoa after 1 h) and the sperm concentration at half the migration distance. The mean of both measures for cervical mucus and hyaluronate solution were equivalent [4.4 +/- 1.1 (SD) versus 4.3 +/- 1.0 cm and 118 +/- 51 versus 111 +/- 44 x 10(3)/ml], and higher than in egg white and albumin Tyrode solution. Antisperm antibodies impaired sperm penetration in cervical mucus and hyaluronate solution in a similar manner (r = 0.92). These results suggest that hyaluronate solution sufficiently resembles human cervical mucus in terms of penetrability that it may be used as a substitutefor mucus in capillary tube tests of sperm function. The higher penetrability of cervical mucus and hyaluronate solution is probably related to a channelling effect due to their polymeric structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:40:49