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Titolo:
Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18
Autore:
Dahlman, I; Wallstrom, E; Weissert, R; Storch, M; Kornek, B; Jacobsson, L; Linington, C; Luthman, H; Lassmann, H; Olsson, T;
Indirizzi:
Karolinska Hosp, Dept Med, Neuroimmunol Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden Karolinska Hosp, Dept Mol Med, Rolf Luft Ctr Diabet Res, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Res, S-17176 Stockholm, Sweden Max Planck Inst Neurobiol, Dept Neuroimmunol, Martinsried, Germany Max Planck Inst Neurobiol Martinsried Germany nol, Martinsried, Germany Univ Vienna, Inst Neurol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Inst Neurol, Vienna, Austria Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Neurol, D-72076 Tubingen, Germany
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 12, volume: 8, anno: 1999,
pagine: 2183 - 2190
SICI:
0964-6906(199911)8:12<2183:LAOMOG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; BASIC-PROTEIN GENE; MULTIPLE-SCLEROSIS PATHOLOGY; SUSCEPTIBILITY LOCI; INDUCED ARTHRITIS; COMPLEX TRAITS; GENOME SCREEN; T-CELL; MICE; PATHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Dahlman, I Karolinska Hosp, Dept Med, Neuroimmunol Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 76 Stockholm, Sweden
Citazione:
I. Dahlman et al., "Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18", HUM MOL GEN, 8(12), 1999, pp. 2183-2190

Abstract

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS) with a complex etiology comprising a genetically determined predisposition and a suspected autoimmune pathogenesis, Experimental autoimmune encephalomyelitis (EAE) is an animal model for MS, which can be used to define susceptibility loci for autoimmune neuroinflammation. We have recently established a chronic relapsing EAE model characterized by inflammation and focal demyelination in the CNS by immunizing avariety of rat strains with the CMS-specific myelin oligodendrocyte glycoprotein (MOG), This model is more MS-like than any other rodent EAE model described up to now. Here we present the first systematic genome search for chromosomal regions linked to phenotypes of MOG-induced EAE in a (DA x ACI) F-2 intercross. A genome-wide significant susceptibility locus linked to demyelination was identified on chromosome 18, This region has not been described in inflammatory diseases affecting other organs and the responsible gene or genes may thus be nervous system specific, Other chromosomal regions showing suggestive linkage to phenotypes of MOG-induced EAE were identifiedon chromosomes 10, 12 and 13, The chromo- some 10 and 12 regions have previously been linked to arthritis in DA rats, suggesting that they harbour immunoregulatory genes controlling general susceptibility to autoimmune diseases. We conclude that identification of susceptibility genes for MOG-induced EAE on rat chromosomes 10, 12, 13 and 18 may disclose important disease pathways for chronic inflammatory demyelinating diseases of the CNS such as MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:34:55