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Titolo:
Acquisition of a stimulatory activity for V gamma 9/V delta 2 T cells by aBurkitt's lymphoma cell line without loss of HLA class I expression
Autore:
LFaqihi, FE; Guiraud, M; Dastugue, N; Brousset, P; Le Bouteiller, P; Halary, F; Bonneville, M; Fournie, JJ; Champagne, E;
Indirizzi:
CHU Purpan, INSERM, U395, F-31024 Toulouse 03, France CHU Purpan Toulouse France 03 INSERM, U395, F-31024 Toulouse 03, France CHU Purpan, Hematol Lab, F-31024 Toulouse, France CHU Purpan Toulouse France F-31024 Hematol Lab, F-31024 Toulouse, France CNRS, UPR8291, Toulouse, France CNRS Toulouse FranceCNRS, UPR8291, Toulouse, France INSERM, U463, Inst Biol, Nantes, France INSERM Nantes FranceINSERM, U463, Inst Biol, Nantes, France
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 10, volume: 60, anno: 1999,
pagine: 928 - 938
SICI:
0198-8859(199910)60:10<928:AOASAF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPEPTIDIC MYCOBACTERIAL LIGANDS; KILLER INHIBITORY RECEPTORS; HUMAN PERIPHERAL-BLOOD; PLASMODIUM-FALCIPARUM; DAUDI CELLS; GAMMA; RECOGNITION; LYMPHOCYTES; ANTIGENS; CLONES;
Keywords:
gamma-delta T lymphocytes; Burkitt's lymphoma; KIR molecules; V gamma 9/V delta 2 T cell receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Champagne, E CHU Purpan, INSERM, U395, BP 3028, F-31024 Toulouse 03, France CHU Purpan BP 3028 Toulouse France 03 24 Toulouse 03, France
Citazione:
F.E. L'Faqihi et al., "Acquisition of a stimulatory activity for V gamma 9/V delta 2 T cells by aBurkitt's lymphoma cell line without loss of HLA class I expression", HUMAN IMMUN, 60(10), 1999, pp. 928-938

Abstract

Daudi Burkitt's lymphoma cells activate V gamma 9/V delta 2 T cells through TCR ligation by an unknown antigen. This activity is for a large parr revealed by their lack of HLA class I antigen expression, allowing their escape from KIR downregulation. We characterize here a culture variant of the Burkitt's lymphoma line Raji, RJ-A3, which is able to promote as efficiently as Daudi cells the outgrowth of V gamma 9/V delta 2 T cells in cocultures in spite of unchanged HLA class Ia/Ib antigen expression. RJ-A3 is resistantto lysis by mosr V gamma 9/V delta 2 lines and clones, even those lacking CD94/NKG2 and p58, p70 p140 KIR molecules. However, one V gamma 9/V delta 2line which can efficiently kill RJ-A3 do so in a TCR-dependent manner since killing is modular-ed by anti-TCR antibodies, The CDR3 sequences of the Tcell clones amplified with Daudi and RJ-A3 reveal that some clones can be expanded with both lines while others are expanded preferentially with one or the other but not both. This indicates differences in the antigenic determinants of the two Burkitt's lines. The occurrence of this Raji variant line demonstrates that the stimulatory phenotype for V gamma 9/V delta 2 cells can be acquired by some rumors independently of the loss of class I antigens and comforts the hypothesis of an anti-tumoral function for the V gamma9/V delta 2 T cell population. (C) American Society for Histocompatibilityand Immunogenetics. 1999 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:30:05