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Titolo:
Nonrandom chromosomal aberrations and cytogenetic heterogeneity in gallbladder carcinomas
Autore:
Gorunova, L; Parada, LA; Limon, J; Jin, YS; Hallen, M; Hagerstrand, I; Iliszko, M; Wajda, Z; Johansson, B;
Indirizzi:
Univ Lund Hosp, Dept Clin Genet, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 pt Clin Genet, SE-22185 Lund, Sweden Med Univ Gdansk, Dept Biol & Genet, Gdansk, Poland Med Univ Gdansk Gdansk Poland Gdansk, Dept Biol & Genet, Gdansk, Poland Univ Lund Hosp, Dept Surg, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Hosp, Dept Surg, S-22185 Lund, Sweden Univ Lund Hosp, Dept Pathol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 sp, Dept Pathol, S-22185 Lund, Sweden Med Univ Gdansk, Dept Surg, Gdansk, Poland Med Univ Gdansk Gdansk Poland ed Univ Gdansk, Dept Surg, Gdansk, Poland
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 4, volume: 26, anno: 1999,
pagine: 312 - 321
SICI:
1045-2257(199912)26:4<312:NCAACH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 PROTEIN EXPRESSION; RAS CODON-12 MUTATIONS; BILIARY-TRACT TUMORS; GENE MUTATION; GALL-BLADDER; C-MYC; CANCER; APC; ADENOCARCINOMAS; REARRANGEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Gorunova, L Univ Lund Hosp, Dept Clin Genet, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 t, SE-22185 Lund, Sweden
Citazione:
L. Gorunova et al., "Nonrandom chromosomal aberrations and cytogenetic heterogeneity in gallbladder carcinomas", GENE CHROM, 26(4), 1999, pp. 312-321

Abstract

Chromosome banding analysis of I I short-term cultured gallbladder carcinomas revealed acquired clonal aberrations in seven tumors (five primary and two metastases). Three of these had one clone, whereas the remaining four were cytogenetically heterogeneous, displaying two to seven aberrant clones. Of a total of 21 abnormal clones, is had highly complex karyotypes and three exhibited simple numerical deviations. Double minutes and homogeneously staining regions were observed in one and two carcinomas, respectively. To characterize the karyotypic profile of gallbladder cancer more precisely, we have combined the present findings with our three previously reported cases, thereby providing the largest cytogenetic database on this tumor type to date. A total of 287 chromosomal breakpoints were identified, 251 of which were found in the present. study. Chromosome 7 was rearranged most frequently, followed by chromosomes 1, 3, 11, 6, 5, and 8. The bands preferentially involved were 1p32, 1p36, 1q32, 3p21, 6p21, 7p13, 7q11, 7q32, 19p13, 19q13, and 22q13. Nine recurrent abnormalities could, for the first time, be identified in gallbladder carcinoma: del(3)(p13), j(5)(p10), del(6)(q13), del(9)(p13), del(16)(q22), del(17)(p11), i(17)(q10), del(19)(p13), and i(21)(q10). The most common partial or whole-arm gains involved 3q, 5p, 7p, 7q, 8q, I Iq, 13q, and 17q, and the most frequent partial or whole-arm losses affected 3p, 4q, 5q, 9p, 10p, 10q, I Ip, 14p, I 4q, 15p, 17p, 19p, 21p, 21q, and Xp. These chromosomal aberrations and imbalances provide some starting points for molecular analyses of genomic regions that may harbor genes of pathogenetic importance in gallbladder carcinogenesis. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:41:09