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Titolo:
Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member
Autore:
Saito, A; Ozaki, K; Fujiwara, T; Nakamura, Y; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710192 7710192, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 Genome, Mol Med Lab, Tokyo 1080071, Japan
Titolo Testata:
GENE
fascicolo: 2, volume: 239, anno: 1999,
pagine: 325 - 331
SICI:
0378-1119(19991101)239:2<325:IAMOAH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACILLUS-CIRCULANS WL-12; MOLECULAR-CLONING; PROTEIN FAMILY; MESSENGER-RNA; CHITOTRIOSIDASE; GLYCOPROTEIN; MACROPHAGES; RESIDUES; DISPLAY; CANCER;
Keywords:
chitinase; lung-specific gene; differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigami, A Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 Kagasuno, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Tokushima Japan 7710192
Citazione:
A. Saito et al., "Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member", GENE, 239(2), 1999, pp. 325-331

Abstract

Using differential display technique, we have isolated a novel human gene expressed specifically in the lung. Two forms of the gene, designated TSA1902, were transcribed by alternate mRNA splicing. The transcribed mRNAs, termed TSA1902-L and TSA1902-S, putatively encode proteins of 368 and 315 amino acids, respectively, which show high similarity to human chitotriosidase protein. The N-terminal region of TSA1902-L protein contains the conserved active site residues (DXXDXDXE) of the catalytic center of various chitinases which are essential for chitinase activity. The deduced protein sequenceof TSA1902-S, however, does not possess this active site, with the N-terminal 54 amino acids present in TSA1902-L protein having been deleted. Both proteins lacked the secretory sequence of N-termini and, judging from the hydropathy profile, may be soluble proteins in the cytoplasm. Chromosomal mapping by radiation hybrid analysis localized this gene to the chromosome 1p13.1-p21.3. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:11:37