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Titolo:
High-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in surfactant-treated rabbits with lung injury
Autore:
Gommers, D; Hartog, A; Schnabel, R; De Jaegere, A; Lachmann, B;
Indirizzi:
Erasmus Univ, Dept Anaesthesiol, NL-3000 DR Rotterdam, Netherlands ErasmusUniv Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Ruhr Univ Bochum, Dept Pathol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 pt Pathol, D-4630 Bochum, Germany Sophia Childrens Hosp, Dept Pediat, Rotterdam, Netherlands Sophia Childrens Hosp Rotterdam Netherlands iat, Rotterdam, Netherlands
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 4, volume: 14, anno: 1999,
pagine: 738 - 744
SICI:
0903-1936(199910)14:4<738:HOVINS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; END-EXPIRATORY PRESSURE; EXOGENOUS SURFACTANT; LAVAGED RABBITS; OXYGENATION; PULMONARY; THERAPY; MODEL;
Keywords:
animal; CMV; HFOV; pulmonary surfactants; rabbit; respiratory distress; ventilator induced lung injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gommers, D Erasmus Univ, Dept Anaesthesiol, Room Ee 2393,POB 1738, NL-3000DR Rotterdam, Netherlands Erasmus Univ Room Ee 2393,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
D. Gommers et al., "High-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in surfactant-treated rabbits with lung injury", EUR RESP J, 14(4), 1999, pp. 738-744

Abstract

The aim of this study was to compare high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation (CMV) with and without surfactant in the treatment of surfactant-deficient rabbits. A previously described saline Lung lavage model of lung injury in adult rabbits was used. The efficacy of each therapy was: assessed by evaluating gas exchange, Lung deflation stability and lung histopathology. Arterial oxygenation did not improve in the CMV group without surfactant but increased rapidly to prelavage values in the other three study groups. During deflation stability, arterial oxygenation decreased to postlavage values In the group that received HFOV alone, but not in both surfactant-treated groups (HFOV and CMV). The HFOV group without surfactant showed more cellular infiltration and epithelial damage compared with both surfactant-treated groups. There was no difference in HFOV gas exchange, lung deflation stability and lung injury between HFOV and CMV after surfactant therapy. It is concluded that the use of surfactant therapy in combination with high-frequency oscillatory: ventilation is not superior to conventional mechanical ventilation in improving gas exchange, lung deflation stability and inthe prevention of lung injury, if lungs are kept expanded. This indicates that achieving and maintaining alveolar expansion (i.e. open lung) is of more importance than the type of ventilator.

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Documento generato il 04/04/20 alle ore 10:43:05