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Titolo:
Pharmacokinetic differences between rat tumour and lung tissues following isolated lung perfusion with cisplatin
Autore:
Li, TS; Kaneda, Y; Saeki, K; Ueda, K; Zempo, N; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 Surg 1, Yamaguchi 7558505, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 13, volume: 35, anno: 1999,
pagine: 1846 - 1850
SICI:
0959-8049(199912)35:13<1846:PDBRTA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY METASTASES; SARCOMA; MODEL; DOXORUBICIN; ESTABLISHMENT;
Keywords:
pharmacokinetics; isolated lung perfusion; lung; tumour; cisplatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Li, TS Yamaguchi Univ, Sch Med, Dept Surg 1, 1144 Kogushi, Yamaguchi 7558505, Japan Yamaguchi Univ 1144 Kogushi Yamaguchi Japan 7558505 7558505, Japan
Citazione:
T.S. Li et al., "Pharmacokinetic differences between rat tumour and lung tissues following isolated lung perfusion with cisplatin", EUR J CANC, 35(13), 1999, pp. 1846-1850

Abstract

Isolated lung perfusion has been performed for the treatment of unresectable lung tumours; however, the pharmacokinetics of this procedure remain unclear. This study was conducted to investigate the changes in antitumour drug concentrations in tumour and lung tissues after isolated lung perfusion, using different perfusion times and perfusate drug concentrations. Isolatedleft lungs were perfused for 20, 40 or 60 min with 25, 50 or 100 mu g/ml of cisplatin after solitary lung tumour nodules were established in rats, and the total platinum concentrations in the perfused lung and tumour tissueswere determined by flameless atomic absorption spectroscopy. The oedema inthe perfused lung tissues was evaluated by histological examination and bythe wet to dry weight ratios of the lungs. The total platinum concentration increased significantly with perfusion time and increasing perfusate cisplatin concentrations in the lung tissue, but it did not change in the tumour tissue. The wet to dry weight ratios of the lung tissues did not differ significantly among the perfusion groups. Oedema of the perfused lung tissuedid not change significantly with the perfusion time or perfusate cisplatin concentration. The results of this study indicate the possibility that different pharmacokinetics exist between tumour and lung tissues following isolated lung perfusion with cisplatin, which could be used as a clinical guide for the selection of appropriate perfusion times and perfusate drug concentrations. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:17:12