Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tuberculosis chemotherapy and sputum conversion among HIV-seropositive andHIV-seronegative patients in south-eastern Uganda
Autore:
Bwire, R; Borgdorff, MW; Sticht-Groh, V; Rieder, HL; Kawuma, HJS; Bretzel, G; Rusch-Gerdes, S;
Indirizzi:
Royal Netherlands TB Assoc, NL-2501 CC The Hague, Netherlands Royal Netherlands TB Assoc The Hague Netherlands NL-2501 CC Netherlands St Francis Leprosy Ctr, Buluba, Uganda St Francis Leprosy Ctr Buluba Uganda rancis Leprosy Ctr, Buluba, Uganda German Leprosy Relief Assoc, Armauer Hansen Inst, Wurzburg, Germany GermanLeprosy Relief Assoc Wurzburg Germany en Inst, Wurzburg, Germany TB Div IUATLD, Bern, Switzerland TB Div IUATLD Bern SwitzerlandTB Div IUATLD, Bern, Switzerland St Francis Leprosy Ctr, Buluba, Uganda St Francis Leprosy Ctr Buluba Uganda rancis Leprosy Ctr, Buluba, Uganda German Leprosy Relief Assoc, Armauer Hansen Inst, Wurzburg, Germany GermanLeprosy Relief Assoc Wurzburg Germany en Inst, Wurzburg, Germany Forschungsinst Borstel, Inst Expt Biol & Med, D-2061 Borstel, Germany Forschungsinst Borstel Borstel Germany D-2061 d, D-2061 Borstel, Germany
Titolo Testata:
EAST AFRICAN MEDICAL JOURNAL
fascicolo: 6, volume: 76, anno: 1999,
pagine: 307 - 313
SICI:
0012-835X(199906)76:6<307:TCASCA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SUB-SAHARAN AFRICA; PULMONARY TUBERCULOSIS; DRUG-RESISTANCE; INFECTION; IMPACT; COHORT; MORTALITY; NAIROBI; KENYA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bwire, R Royal Netherlands TB Assoc, POB 146, NL-2501 CC The Hague, Netherlands Royal Netherlands TB Assoc POB 146 The Hague Netherlands NL-2501 CC
Citazione:
R. Bwire et al., "Tuberculosis chemotherapy and sputum conversion among HIV-seropositive andHIV-seronegative patients in south-eastern Uganda", E AFR MED J, 76(6), 1999, pp. 307-313

Abstract

Objective: To investigate if there is a difference in response to tuberculosis treatment between HIV seronegative and HIV seropositive patients following two months of intensive phase tuberculosis treatment. Design: Prospective cohort study. Setting: St. Francis Leprosy Centre, south-east Uganda,Subjects: Four hundred fifty seven patients with never previously treated sputum smear-positive tuberculosis admitted during a two-year period in 1991/1993,Intervention: Intensive phase treatment with streptomycin, isoniazid, rifampicin and pyrazinamide,Main outcome measures: Sputum conversion from a positive to a negative smear at eight weeks of treatment. Results: HIV seropositivity prevalence was 28%, Among HIV seronegative patients, conversion to a negative smear status occurred in 76% persons compared to 78% in HIV seropositive patients. This difference was not statistically significant (OR = 0.9; 95% CI, 0.6-1.5). HIV seropositive patients, however, were more likely to die (p = 0.017), A high prevalence of resistance to isoniazid and streptomycin was found, Isoniazid resistance was more likely in HIV seronegative patients with M, tuberculosis strains compared to HIVseropositive persons (p < 0.005). Initial resistance to antituberculosis drugs did not have a significant effect on smear conversion. Conclusion: This study demonstrates that HIV-seropositive status is not a principal factor in delaying sputum conversion among patients receiving intensive phase tuberculosis treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:04:42