Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Noninvasive C-13-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis
Autore:
Toepfer, M; Folwaczny, C; Lochmuller, H; Schroeder, M; Riepl, RL; Pongratz, D; Muller-Felber, W;
Indirizzi:
Univ Munich, Klinikum Innenstadt, Friedrich Baur Inst, Dept Gastroenterol,D-80336 Munich, Germany Univ Munich Munich Germany D-80336 Gastroenterol,D-80336 Munich, Germany
Titolo Testata:
DIGESTION
fascicolo: 6, volume: 60, anno: 1999,
pagine: 567 - 571
SICI:
0012-2823(199911/12)60:6<567:NCABTS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; AUTONOMIC FUNCTION; CONTROLLED TRIAL; ABNORMALITIES; VARIABILITY; DISORDERS; LIQUID;
Keywords:
amyotrophic lateral sclerosis; gastric emptying; C-13-octanoic acid breath test; autonomic involvement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Toepfer, M Univ Munich, Klinikum Innenstadt, Friedrich Baur Inst, Dept Gastroenterol,Ziemssenstr 1, D-80336 Munich, Germany Univ Munich Ziemssenstr 1Munich Germany D-80336 nich, Germany
Citazione:
M. Toepfer et al., "Noninvasive C-13-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis", DIGESTION, 60(6), 1999, pp. 567-571

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems. Subclinical involvement of theautonomic system in ALS has been described. The recently developed C-13-octanoic acid breath test allows the noninvasive measurement of gastric emptying. With this new technique we investigated 18 patients with ALS and 14 healthy volunteers. None of the patients had diabetes mellitus or other disorders known to cause autonomic dysfunction. The participants received a solid standard test meal labeled with C-13-octanoic acid. Breath samples were taken at 15-min intervals for 5 h and were analyzed for (CO2)-C-13 by isotope selective nondispersive infrared spectrometry. Gastric emptying peak time(t(peak)) and emptying half time (t(1/2)) were determined. All healthy volunteers displayed normal gastric emptying with a mean emptying t(1/2) of 138 +/- 34 (range 68-172) min. Gastric emptying was delayed (t(1/2) > 160 min) in 15 of 18 patients with ALS. Emptying t(1/2) in ALS patients was 218 +/- 48 (range 126-278) min (p < 0.001). These results are compatible with autonomic involvement in patients with ALS, causing delayed gastric emptying of solids and encouraging the theory that ALS is a multisystem disease rather than a disease of the motor neurons only.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:54:24