Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analysis of beta-catenin gene mutations in pancreatic tumors
Autore:
Gerdes, B; Ramaswamy, A; Simon, B; Pietsch, T; Bastian, D; Kersting, M; Moll, R; Bartsch, D;
Indirizzi:
Univ Marburg, Dept Gen Surg, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 Gen Surg, D-35033 Marburg, Germany Univ Marburg, Dept Pathol, D-35033 Marburg, Germany Univ Marburg MarburgGermany D-35033 pt Pathol, D-35033 Marburg, Germany Univ Marburg, Dept Internal Med, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 ernal Med, D-35033 Marburg, Germany Univ Bonn, Med Ctr, Dept Neuropathol, Bonn, Germany Univ Bonn Bonn Germany v Bonn, Med Ctr, Dept Neuropathol, Bonn, Germany
Titolo Testata:
DIGESTION
fascicolo: 6, volume: 60, anno: 1999,
pagine: 544 - 548
SICI:
0012-2823(199911/12)60:6<544:AOBGMI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR CARCINOMAS; SOMATIC MUTATIONS; E-CADHERIN; FREQUENT; APC; CANCER; ACTIVATION;
Keywords:
beta-catenin; CTNNB1; beta-catenin-Tcf pathway; pancreatic tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gerdes, B Univ Marburg, Dept Gen Surg, Baldingerstr, D-35033 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35033 burg, Germany
Citazione:
B. Gerdes et al., "Analysis of beta-catenin gene mutations in pancreatic tumors", DIGESTION, 60(6), 1999, pp. 544-548

Abstract

Background/Aim: Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been described in a subset of pancreatic carcinomas. TheAPC gene modulates the beta-catenin-Tcf pathway. The major player in this pathway is the beta-catenin protein encoded by the beta-catenin gene. A variety of different tumors, including colon, prostate, endometrial, and hepatocellular carcinomas, carry mutations in exon 3 of the beta-catenin gene. The aim of this study was to determine the role of the beta-catenin gene in the genesis of exocrine and endocrine tumors of the pancreas. Methods: 78 ductal pancreatic adenocarcinomas, 14 ductal pancreatic cancer cell lines, and 33 endocrine pancreatic tumors were evaluated for mutations in exon 3 ofthe beta-catenin gene by single-strand conformation polymorphism analysis and direct DNA sequencing. in addition, 40 ductal pancreatic adenocarcinomas were analyzed for intracellular beta-catenin accumulation by immunohistochemistry, indicating alterations of the beta-catenin gene. Results: Neitherthe 111 exocrine and endocrine pancreatic tumors nor the 14 pancreatic cancer cell lines carried mutations in exon 3 of the beta-catenin gene. Intracellular beta-catenin accumulation was not identified in any of the 40 pancreatic adenocarcinomas. Conclusion: These data suggest that the beta-cateningene as the major player of the beta-catenin-Tcf pathway does not play an important role in the genesis of pancreatic tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:58:38