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Titolo:
Prefrontal cortical involvement in visual working memory
Autore:
Nielsen-Bohlman, L; Knight, RT;
Indirizzi:
Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Psychol, Berkeley, CA 94720 USA Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 3, volume: 8, anno: 1999,
pagine: 299 - 310
SICI:
0926-6410(19991025)8:3<299:PCIIVW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; SHORT-TERM-MEMORY; TEMPORAL-LOBE LESIONS; RECOGNITION MEMORY; FRONTAL-CORTEX; RHESUS-MONKEY; INTRACEREBRAL POTENTIALS; RARE TARGET; DISCRIMINATION TASKS; SELECTIVE ATTENTION;
Keywords:
working memory; aging; human; P3; N4; dorsolateral frontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Knight, RT Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 3210 Tolman Hall Berkeley CA USA 94720 USA
Citazione:
L. Nielsen-Bohlman e R.T. Knight, "Prefrontal cortical involvement in visual working memory", COGN BRAIN, 8(3), 1999, pp. 299-310

Abstract

Studies of human amnesia provide evidence for a short-term memory store with information transfer to long term memory occurring within 60 a of sensory encoding. Human and nonhuman primate research has shown that maintenance of this short-term or working memory store is dependent upon frontal cortical activation, although the critical temporal parameters of frontal involvement throughout this 60-s window are undetermined. We examined prefrontal contributions to rapid (under 2 s) and sustained (over 4 s) visual working memory by recording behavioral performance and event-related potentials (ERPs) in patients with lesions in dorsolateral frontal cortex and age-matched control subjects. Prefrontal lesioned patients generated a reduced sustained frontal positivity at all delays. At short delays, patients generated reduced performance to stimuli presented in the contralesional field. Patientsgenerated a negative potential (N400), greatest to contralesionally presented stimuli, that was observed in the control subjects only at long delays. The results indicate that prefrontal lesions impair the frontal component of an anterior-posterior working memory network activated during rapid and sustained visual memory processing. Frontal patients may require activationof limbic cortex, indexed by N400, for maintenance of both rapid and sustained working memory. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 13:19:44