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Titolo:
Detection of presymptomatic atherosclerosis: a current perspective
Autore:
Adams, MR; Celermajer, DS;
Indirizzi:
Royal Prince Alfred Hosp, Dept Cardiol, Sydney, NSW 2050, Australia Royal Prince Alfred Hosp Sydney NSW Australia 2050 y, NSW 2050, Australia Heart Res Inst, Sydney, NSW 2050, Australia Heart Res Inst Sydney NSW Australia 2050 nst, Sydney, NSW 2050, Australia
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 5, volume: 97, anno: 1999,
pagine: 615 - 624
SICI:
0143-5221(199911)97:5<615:DOPAAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ENDOTHELIUM-DEPENDENT DILATION; INTIMA-MEDIA THICKNESS; ISCHEMIC-HEART-DISEASE; BEAM COMPUTED-TOMOGRAPHY; COMMON CAROTID-ARTERY; HEALTHY-YOUNG ADULTS; INTRAVASCULAR ULTRASOUND; RISK-FACTORS; L-ARGININE;
Keywords:
atherosclerosis; endothelium; nitric oxide; ultrasound;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Celermajer, DS Royal Prince Alfred Hosp, Dept Cardiol, Missenden Rd, Sydney, NSW 2050, Australia Royal Prince Alfred Hosp Missenden Rd Sydney NSW Australia 2050
Citazione:
M.R. Adams e D.S. Celermajer, "Detection of presymptomatic atherosclerosis: a current perspective", CLIN SCI, 97(5), 1999, pp. 615-624

Abstract

Atherosclerosis, the pathological process underlying myocardial infarction, stroke and other occlusive vascular disease, is the major cause of death in the Western world. The development of techniques to accurately and reproducibly detect and measure the early changes of atherosclerosis and/or to identify subjects at highest cardiovascular risk may aid in the development of prevention strategies and facilitate a decrease in morbidity and mortality from atherosclerosis. Increasing understanding of the pathophysiology ofearly atherosclerosis has allowed the development of a number of potentialmethods for the assessment of the early stages of atherosclerosis in humans. These include techniques for assessing early structural changes in the coronary arteries with electron-beam computed tomography and magnetic resonance imaging. External vascular ultrasound has also been used to image othercirculations as a surrogate marker for coronary atherosclerosis, e.g. the measurement of carotid artery intima-media thickness. Early functional changes of atherosclerosis have also been described many years before the development of structural changes. A number of techniques have been developed tomeasure endothelial dysfunction, one of the earliest changes of atherosclerosis, including noninvasive measurement of endothelial function using external vascular ultrasound. A variety of serum markers have also been described, and may be useful markers of atherosclerosis. We discuss some of the more promising techniques for the detection of early, presymptomatic atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:21:21