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Titolo:
Short-term variations in oscillatory and spirometric lung function parameters of non-asthmatic adults
Autore:
Randell, JT; Salonen, RO; Pekkarinen, H; Tukiainen, H;
Indirizzi:
Kuopio Univ Hosp, Dept Resp Med, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 Med, FIN-70211 Kuopio, Finland Natl Publ Hlth Inst, Dept Environm Med, Kuopio, Finland Natl Publ Hlth Inst Kuopio Finland , Dept Environm Med, Kuopio, Finland Univ Kuopio, Dept Physiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Physiol, FIN-70211 Kuopio, Finland
Titolo Testata:
CLINICAL PHYSIOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 329 - 337
SICI:
0144-5979(199907)19:4<329:SVIOAS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL RESPIRATORY RESISTANCE; FORCED OSCILLATION; HEALTHY-SUBJECTS; HISTAMINE; VOLUME; VARIABILITY; CHALLENGE; CHILDREN; CURVE; AREA;
Keywords:
healthy adults; intra-subject variation; lung function; oscillatory resistance; reliability index; spirometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Randell, JT Kuopio Univ Hosp, Dept Resp Med, POB 1777, FIN-70211 Kuopio, Finland Kuopio Univ Hosp POB 1777 Kuopio Finland FIN-70211 o, Finland
Citazione:
J.T. Randell et al., "Short-term variations in oscillatory and spirometric lung function parameters of non-asthmatic adults", CLIN PHYSL, 19(4), 1999, pp. 329-337

Abstract

Oscillatory respiratory resistance (Rrs(fo)) at 8 Hz was compared to flow-volume spirometry with regard to immediate, within-day, day-to-day and week-to-week variations in seven female and four male non-smoking, non-asthmatic volunteers. The lung functions were measured at 08:00, 12:00, 16:00 and 20:00 h on each of the four study days, i.e. two consecutive days in two consecutive weeks. During each visit:there were three immediately repeated measurements of Rrs(fo), followed by three spiro-metric recordings. The intra-subject coefficient of variation (Coeff(var)) for the immediately repeated measurements was largest for Rrs(fo) (11.8%). When a simple reliability index (+/-2 SD of the differences between the repeated measurements) was applied to the Rrs(fo) data, the Coeff(var) reduced to 7.5%. In spirometry, the airflow parameters at defined lung volumes showed larger immediate variations (MEF50 = 5.6%, MEF25 = 8.3%, MMEF = 4.4%) than FEV1 (1.5%) and PEF (3.2%), The within-day variations were larger than the day-to-day or week-to-week variations, and the variations were largest in Rrs(fo). A significant diurnal pattern was Shown in spirometric parameters but not in Rrs(fo). About 38% of the total variance in Rrs(fo) was due to variation: within subjects,while the corresponding proportions in spirometric parameters were 1.8-18.4%. In conclusion, Rrs(fo) showed larger intrasubject variations than the spirometric parameters at all:time intervals. Application of a simple reliability index and standardization of the time of day of the measurement reduced the variations and improved the quality of the Rrs(fo) data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:11:40