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Titolo:
Simple forced oscillatory technique and spirometry in assessment of bronchial responsiveness in non-asthmatic and asthmatic subjects
Autore:
Randell, JT; Salonen, RO; Tukiainen, H;
Indirizzi:
Kuopio Univ Hosp, Dept Resp Med, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 Med, FIN-70211 Kuopio, Finland Natl Publ Hlth Inst, Dept Environm Med, Kuopio, Finland Natl Publ Hlth Inst Kuopio Finland , Dept Environm Med, Kuopio, Finland Univ Kuopio, Dept Physiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Physiol, FIN-70211 Kuopio, Finland
Titolo Testata:
CLINICAL PHYSIOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 321 - 328
SICI:
0144-5979(199907)19:4<321:SFOTAS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL RESPIRATORY RESISTANCE; HISTAMINE; REACTANCE;
Keywords:
airway responsiveness; oscillatory resistance; spirometry; healthy subjects; asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Randell, JT Kuopio Univ Hosp, Dept Resp Med, POB 1777, FIN-70211 Kuopio, Finland Kuopio Univ Hosp POB 1777 Kuopio Finland FIN-70211 o, Finland
Citazione:
J.T. Randell et al., "Simple forced oscillatory technique and spirometry in assessment of bronchial responsiveness in non-asthmatic and asthmatic subjects", CLIN PHYSL, 19(4), 1999, pp. 321-328

Abstract

Simple validity controlled forced oscillatory respiratory resistance (Rrs(fo)) at 8 Hz frequency was compared with flow-volume spirometry in detection of bronchial changes during induced bronchoconstriction. The methacholineprovocation test was performed in subjects with mild asthma (n = 18) and in non-asthmatic subjects (n = 61) of which 44 were classified as responders(Delta FEV1 greater than or equal to 15% in methacholine: test).:Accordingto the index of maximal response/coefficient of variation for immediately repeated measurements (Delta(max)/Coeff(var)), Rrs(fo) was shown to be at least as sensitive indicator of bronchoconstriction as FEV1, and better thanMMEF and FVC. The shape of the dose-response curves were similar for all parameters. In the non-asthmatic group, there n ere similar plateaux in Rrs(fo), FEV1, and FVC at the same methacholine concentrations. In the asthmatic group, the provocative concentrations for Rrs(fo) and spirometric parameters correlated significantly (PC60-Rrs(fo) versus PC10-FEV1, P<0.05; PC60-Rrs(fo) versus PC25-MMEF, P<0.01). In the non-asthmatic responsive subjects,the correlations between PC60-Rrs(fo) and PC25-MMEF were significant (P<0.05). Thus, Rrs(fo) at a fixed 8 Hz frequency and built-in validity control was shown to be at least as sensitive an indicator for changes in lung function in asthmatic and non-asthmatic responsive subjects as spirometry. Compared to spirometry, it may give additional information with fewer confounding factors during performance.

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Documento generato il 05/04/20 alle ore 06:37:53