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Titolo:
Laminins during muscle development and in muscular dystrophies
Autore:
Gullberg, G; Tiger, CF; Velling, T;
Indirizzi:
Uppsala Univ BMC, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden Uppsala Univ BMC Uppsala Sweden S-75124 ol Biol, S-75124 Uppsala, Sweden
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 5-6, volume: 56, anno: 1999,
pagine: 442 - 460
SICI:
1420-682X(19991030)56:5-6<442:LDMDAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-7 INTEGRIN RECEPTOR; MEDIATES CELL-ADHESION; TENASCIN-C EXPRESSION; ADULT SKELETAL-MUSCLE; EMBRYONIC STEM-CELLS; PROTEIN S-LAMININ; BASEMENT-MEMBRANE; BETA-1 INTEGRIN; EXTRACELLULAR-MATRIX; MYOGENIC CELLS;
Keywords:
somite; muscle development; muscular dystrophy; laminin isoforms;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
156
Recensione:
Indirizzi per estratti:
Indirizzo: Gullberg, G Uppsala Univ BMC, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden Uppsala Univ BMC Box 596 Uppsala Sweden S-75124 psala, Sweden
Citazione:
G. Gullberg et al., "Laminins during muscle development and in muscular dystrophies", CELL MOL L, 56(5-6), 1999, pp. 442-460

Abstract

Cellular interactions with the extracellular matrix during muscle formation and in muscular dystrophy have received increased interest during the past years. Laminins constitute a growing family of proteins with complex expression patterns in forming basement membranes during muscle development. Inskeletal muscle, laminins constitute major ligands for cell surface receptors involved in the transmission of force from the cell interior, but laminins might also influence signal transmission events during muscle formationand in muscle regeneration. During myogenesis the laminin eel chain is present around the epithelial somite; but later, in forming muscle, the laminin alpha 1 chain is restricted to the myotendinous junction. The laminin alpha 2, alpha 4 and alpha 5 chains are major laminin chains in the muscle basement membrane during muscle formation, but laminin alpha 4 and alpha 5 chains are absent in adult muscle. The importance of laminins for muscle integrity is manifested in congenital muscular dystrophies with defects in the laminin alpha 2 chain. There is no good evidence for the presence of lamininalpha 1 chain in dystrophic muscle, but some other fetal muscle laminins can be detected in dystrophic muscle. Characterization of laminin expressionpatterns in muscular dystrophies might be of diagnostic and therapeutic value. In this paper. we review the recent publications on the biological functions of muscle laminins and discuss their roles in skeletal muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:25:25