Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccalpouch carcinogenesis
Autore:
Balasenthil, S; Arivazhagan, S; Ramachandran, CR; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
CANCER DETECTION AND PREVENTION
fascicolo: 6, volume: 23, anno: 1999,
pagine: 534 - 538
SICI:
0361-090X(1999)23:6<534:EOGO7H>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE; SELENIUM; TISSUES;
Keywords:
antioxidants; chemoprevention; DMBA; garlic; lipid peroxidation; oral cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil et al., "Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccalpouch carcinogenesis", CANCER DET, 23(6), 1999, pp. 534-538

Abstract

The inhibitory effect of garlic (Allium sativum Linn) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced buccal pouch carcinogenesis was investigated in male Syrian hamsters. Measurement of lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) was used to monitor the chemopreventive potential of garlic. All hamsterspainted on their buccal pouches with DMBA alone for 14 weeks developed well-differentiated squamous cell carcinomas. Diminished lipid peroxidation inthe oral tumor tissue was accompanied by a significant increase in the levels of GSH, GPx, and GST. Administration of 250 mg/kg body weight aqueous garlic extract three times a week for 14 weeks effectively suppressed DMBA-induced oral carcinogenesis as revealed by the reduced incidence of neoplasms. The results of the present study suggest that garlic may exert its chemopreventive effects by modulating lipid peroxidation and enhancing the levels of GSH, GPx, and GST.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:20:25