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Titolo:
Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline
Autore:
Irifune, M; Sugimura, M; Takarada, T; Maeoka, K; Shimizu, Y; Dohi, T; Nishikawa, T; Kawahara, M;
Indirizzi:
Hiroshima Univ, Sch Dent, Dept Anaesthesiol, Minami Ku, Hiroshima 7348553,Japan Hiroshima Univ Hiroshima Japan 7348553 inami Ku, Hiroshima 7348553,Japan Hiroshima Univ, Sch Dent, Dept Pharmacol, Minami Ku, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 nami Ku, Hiroshima 7348553, Japan Kagoshima Univ, Sch Dent, Dept Pharmacol, Kagoshima 8908544, Japan Kagoshima Univ Kagoshima Japan 8908544 armacol, Kagoshima 8908544, Japan
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 4, volume: 83, anno: 1999,
pagine: 665 - 667
SICI:
0007-0912(199910)83:4<665:PAIMIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERAL-ANESTHETICS; SYNAPTOSOMES; RELEASE; DRUGS;
Keywords:
anaesthetics i.v., propofol; brain, GABA; pharmacology, muscimol; pharmacology, bicuculline; mouse; receptors, amino acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Irifune, M Hiroshima Univ, Sch Dent, Dept Anaesthesiol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348553 553, Japan
Citazione:
M. Irifune et al., "Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline", BR J ANAEST, 83(4), 1999, pp. 665-667

Abstract

We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent mannerwith an ED50 value of 140 (95% confidence limits 123-160) mg kg(-1) (n = 40; eight animals per dose, five doses per dose-response curve). The ED50 for propofol decreased significantly to 66 (58-75) mg kg(-1) in the presence of the GABA(A) receptor agonist muscimol 1 mg kg(-1) i.p. (n = 40) (P < 0.05). In contrast, the ED50 increased significantly to 240 (211-274) mg kg(-1) in the presence of the antagonist bicuculline 5 mg kg(-1) i.p. (n = 40) (P < 0.05). Our results suggest that propofol anaesthesia may be mediated, at least in part, by GABA neurones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:05:56