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Titolo:
Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block
Autore:
De Lima, J; Alvares, D; Hatch, DJ; Fitzgerald, M;
Indirizzi:
Portex Dept Anaesthesia, London WC1N 3EH, England Portex Dept AnaesthesiaLondon England WC1N 3EH London WC1N 3EH, England Univ Coll London, Dept Anat & Dev Biol, London WC1E 6BT, England Univ CollLondon London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 4, volume: 83, anno: 1999,
pagine: 662 - 664
SICI:
0007-0912(199910)83:4<662:SHANSW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
REINNERVATION; GROWTH;
Keywords:
anaesthetics local, bupivacaine; hyperinnervation, regional; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: De Lima, J Portex Dept Anaesthesia, Guilford St, London WC1N 3EH, England Portex Dept Anaesthesia Guilford St London England WC1N 3EH nd
Citazione:
J. De Lima et al., "Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block", BR J ANAEST, 83(4), 1999, pp. 662-664

Abstract

The response to tissue injury includes sensitization of peripheral nociceptors and central neuronal pathways leading to acute clinical and inflammatory pain. A further response is sprouting of sensory nerve terminals in the region of skin damage. This hyperinnervation response is particularly intense in neonates compared with adults. In this study, we tested the effect ofregional nerve block at the time of injury on skin hyperinnervation. Anaesthetized newborn rat pups were treated with percutaneous sciatic nerve block injections of 0.25% bupivacaine 25 mu l followed by a localized hindpaw skin wound. Cutaneous innervation was studied by image analysis of immunostained skin sections, 7 days after wounding. and sensory thresholds were assessed using von prey hairs. The results showed that both hyperinnervation and hypersensitivity were not significantly altered by the application of a regional nerve block at the time of injury. This suggests that regional analgesia, used commonly in clinical practice, is unlikely to prevent the hyperinnervation that follows skin wounding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 20:54:11