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Titolo:
Prognostic implications of the differentiation inhibitory factor nm23-H1 protein in the plasma of aggressive non-Hodgkin's lymphoma
Autore:
Niitsu, N; Okabe-Kado, J; Kasukabe, T; Yamamoto-Yamaguchi, Y; Umeda, M; Honma, Y;
Indirizzi:
Saitama Canc Ctr, Res Inst, Kita Adachi, Saitama 3620806, Japan Saitama Canc Ctr Kita Adachi Saitama Japan 3620806 Saitama 3620806, Japan Toho Univ, Sch Med, Dept Internal Med 1, Tokyo, Japan Toho Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 1, Tokyo, Japan
Titolo Testata:
BLOOD
fascicolo: 10, volume: 94, anno: 1999,
pagine: 3541 - 3550
SICI:
0006-4971(19991115)94:10<3541:PIOTDI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOSIDE DIPHOSPHATE KINASE; COLONY-STIMULATING FACTOR; MYELOID-LEUKEMIA CELLS; FACTOR G-CSF; INTERMEDIATE-GRADE; NM23/NDP KINASE; MACOP-B; GENE; EXPRESSION; CYCLOPHOSPHAMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Okabe-Kado, J Saitama Canc Ctr, Res Inst, 818 Komuro, Kita Adachi, Saitama3620806, Japan Saitama Canc Ctr 818 Komuro Kita Adachi Saitama Japan 3620806
Citazione:
N. Niitsu et al., "Prognostic implications of the differentiation inhibitory factor nm23-H1 protein in the plasma of aggressive non-Hodgkin's lymphoma", BLOOD, 94(10), 1999, pp. 3541-3550

Abstract

The outcome of patients with non-Hodgkin's lymphoma has been improved by current approaches to treatment. Nevertheless, many patients either do not have a complete remission or ultimately relapse, To identify such patients, it is important to be able to predict the outcome. We previously found thatthe differentiation inhibitory factor/nm23 was correlated with the prognosis of acute myeloid leukemia. To examine the prognostic effect of nm23 on non-Hodgkin's lymphoma, we established an enzyme-linked immunosorbent assay procedure to determine nm23-H1 protein levels in plasma and assessed the association of this protein level with the response to chemotherapy, overall survival, and progression-free survival in patients with aggressive non-Hodgkin's lymphoma. The plasma concentration of nm23-H1 was significantly higher in patients with malignant lymphoma than in normal controls, especially in aggressive non-Hodgkin's lymphoma. The complete remission rate in patients with higher nm23-H1 levels was significantly worse than that in patientswith lower nm23-H1 levels. Overall survival and progression-free survival were also lower in patients with higher nm23-H1 levels than in those with lower levels. The 3-year survival rates in patients with low and high nm23-H1 levels were 79.5% and 6.7% (P = .0001). A multivariate analysis of prognostic factors showed that the plasma nm23-H1 level was independently associated with the survival and progression-free survival. An elevated plasma nm23-H1 concentration predicts a poor outcome of advanced non-Hodgkin's lymphoma. Therefore, nm23-H1 in plasma may be useful for identifying a distinct group of patients at very high risk. (C) 1999 by The American Society of Hematology.

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Documento generato il 06/04/20 alle ore 08:45:26