Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Caspase-3 activation during the process of apoptosis induced by a vacuolartype H+-ATPase inhibitor
Autore:
Ishisaki, A; Hashimoto, S; Amagasa, T; Nishihara, T;
Indirizzi:
Natl Inst Infect Dis, Dept Oral Sci, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Tokyo Med & Dent Univ, Fac Dent, Dept Oral & Maxillofacial Surg 1, Tokyo 1138549, Japan Tokyo Med & Dent Univ Tokyo Japan 1138549 l Surg 1, Tokyo 1138549, Japan
Titolo Testata:
BIOLOGY OF THE CELL
fascicolo: 7, volume: 91, anno: 1999,
pagine: 507 - 513
SICI:
0248-4900(199909)91:7<507:CADTPO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ICE-LIKE PROTEASE; KINASE-C-DELTA; CELL-DEATH; IN-VITRO; INTERLEUKIN-1-BETA-CONVERTING ENZYME; POLY(ADP-RIBOSE) POLYMERASE; PROTEOLYTIC ACTIVATION; RETINOBLASTOMA PROTEIN; FAMILY PROTEASES; MITOTIC EXTRACTS;
Keywords:
caspase; apoptosis; concanamycin A; vacuolar type H+-ATPase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Nishihara, T Natl Inst Infect Dis, Dept Oral Sci, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan Natl Inst Infect Dis 1-23-1 Toyama Tokyo Japan 1628640 Japan
Citazione:
A. Ishisaki et al., "Caspase-3 activation during the process of apoptosis induced by a vacuolartype H+-ATPase inhibitor", BIO CELL, 91(7), 1999, pp. 507-513

Abstract

Concanamycin A, a specific inhibitor of vacuolar type Hf-ATPases, induced DNA fragmentation in B cell hybridoma HS-72 cells. Immunoblot analysis revealed that the exposure of concanamycin A to HS-72 cells induced the cleavage of retinoblastoma protein (Rb) and poly(ADP-ribose) polymerase (PARP). The cytosol from concanamycin A-treated HS-72 cells induced DNA fragmentationin nuclei from untreated cells in a cell-free system. This fragmentation was suppressed by a specific inhibitor of caspase-3. The cytosol induced Rb proteolysis in vitro, which was inhibited by a caspase-3 inhibitor. These findings indicate that caspase-3 induces DNA fragmentation and cleavage of Rb and PARP during the process of apoptosis induced by concanamycin A. (C) Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 03:53:31