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Titolo:
The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A
Autore:
Chakrabarti, SR; Nucifora, G;
Indirizzi:
Loyola Univ, Med Ctr, Inst Oncol, Cardinal Bernardin Canc Ctr, Maywood, IL60153 USA Loyola Univ Maywood IL USA 60153 Bernardin Canc Ctr, Maywood, IL60153 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 264, anno: 1999,
pagine: 871 - 877
SICI:
0006-291X(19991102)264:3<871:TLGTEA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; HISTONE DEACETYLASE; N-COR; FUSION; INTERACTS; PROTEIN; COMPLEX; TRANSLOCATION; ONCOPROTEIN; ETV6/CBFA2;
Keywords:
TEL; mSin3A; SMRT; N-CoR; transcription repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nucifora, G Loyola Univ, Med Ctr, Inst Oncol, Cardinal Bernardin Canc Ctr,2160 S 1st Ave, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave Maywood IL USA 60153 , IL 60153 USA
Citazione:
S.R. Chakrabarti e G. Nucifora, "The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A", BIOC BIOP R, 264(3), 1999, pp. 871-877

Abstract

The E-26 transforming specific (ETS)-related gene TEL, also known as ETV6,encodes a strong transcription repressor that is rearranged in several recurring chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. The TEL protein contains two functional domains that have beenpartially characterized: a helix-loop-helix (HLH) domain (also known as a pointed domain) at the N-terminus, which physically interacts with itself, with the SUMO-conjugating enzyme UBC9, and with FLI1; and, at the C-terminus, an ETS domain with DNA-binding properties. Little is known about the function of the central region of TEL. The HLH domain and the central region of TEL are consistently maintained in the t(12;21), which is the most frequent chromosomal translocation involving TEL. In this study, we found that the HLH domain and the central region of TEL mediate transcription repressionby two distinct mechanisms. The central region involves the recruitment ofa repression complex, including SMRT and mSin3A. The HLH domain represses gene transcription through a mechanism that is independent of known corepressors. Thus, TEL belongs to a growing number of transcription factors rearranged by chromosomal translocations that are associated with the corepressor complexes. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:21:55