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Titolo:
Aging and time-of-day effects on cognition in rats
Autore:
Winocur, G; Hasher, L;
Indirizzi:
Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6C 2J4, Canada Baycrest Ctr Geriatr Care Toronto ON Canada M6C 2J4 o, ON M6C 2J4, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Psychol, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Duke Univ, Dept Psychol, Durham, NC 27706 USA Duke Univ Durham NC USA 27706 ke Univ, Dept Psychol, Durham, NC 27706 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 5, volume: 113, anno: 1999,
pagine: 991 - 997
SICI:
0735-7044(199910)113:5<991:AATEOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; CIRCADIAN-RHYTHMS; INDIVIDUAL-DIFFERENCES; PREFRONTAL CORTEX; SLEEP; INTERFERENCE; HIPPOCAMPUS; DECLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Winocur, G Baycrest Ctr Geriatr Care, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6C 2J4, Canada Baycrest Ctr Geriatr Care 3560 Bathurst St Toronto ON Canada M6C 2J4
Citazione:
G. Winocur e L. Hasher, "Aging and time-of-day effects on cognition in rats", BEHAV NEURO, 113(5), 1999, pp. 991-997

Abstract

This study used an animal model to investigate the importance of the time at which testing occurs for age differences in learning and memory. Groups of old and young rats were entrained to a 12-hr light-dark schedule and administered tests of delayed alternation and inhibitory avoidance conditioning at the beginning or end of their high-activity cycle. Apart from normal age differences in test performance, the behavioral results demonstrated that old but not young rats were affected by the time of testing. In both tasks, old rats tested late in the activity cycle performed significantly worsethan did old rats tested early in the cycle, under conditions that challenged memory processes that are known to involve the hippocampus. The resultsindicate that circadian disruption in old age can adversely affect memory and related cognitive function, with important implications for inhibitory control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:49:24