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Titolo:
Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
Autore:
Dodart, JC; Meziane, H; Mathis, C; Bales, KR; Paul, SM; Ungerer, A;
Indirizzi:
Univ Strasbourg 1, CNRS, URA 1295, F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 , F-67000 Strasbourg, France Lilly Res Labs, Div Neurosci, Indianapolis, IN USA Lilly Res Labs Indianapolis IN USA s, Div Neurosci, Indianapolis, IN USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 5, volume: 113, anno: 1999,
pagine: 982 - 990
SICI:
0735-7044(199910)113:5<982:BDITMO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBJECT-RECOGNITION MEMORY; ALZHEIMER-DISEASE; NEUROTOXIC LESIONS; FORNIX TRANSECTION; PERIRHINAL CORTEX; RATS; DEFICITS; DEPOSITION; PEPTIDES; INCREASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Dodart, JC Univ Strasbourg 1, CNRS, URA 1295, Rue Univ, F-67000 Strasbourg, France Univ Strasbourg 1 Rue Univ Strasbourg France F-67000 g, France
Citazione:
J.C. Dodart et al., "Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein", BEHAV NEURO, 113(5), 1999, pp. 982-990

Abstract

PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after amyloid deposition. PDAPP mice manifest robust impairments in a radial-maze spatial discrimination task at all ages tested. Mild deficits were observed in a barpress learning task in S-month-old PDAPP mice. In contrast, PDAPP mice show an age-dependent decrease in spontaneous object-recognition performance that appears to be severe at ages when amyloid deposition is known to occur. Thus, the PDAPP mouse shows severe deficits inthe radial maze well before amyloid plaque deposition, whereas object-recognition performance decreases with age and may be associated with amyloid deposition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:01:18