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Titolo:
The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition
Autore:
Pouzet, B; Feldon, J; Veenman, CL; Yee, BK; Richmond, M; Rawlins, JNP; Weiner, I;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Peoples R China at, Hong Kong, Peoples R China Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 sychol, IL-69978 Tel Aviv, Israel
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 5, volume: 113, anno: 1999,
pagine: 968 - 981
SICI:
0735-7044(199910)113:5<968:TEOHAF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-GLUTAMATE INTERACTIONS; ACOUSTIC STARTLE RESPONSE; NUCLEUS-ACCUMBENS; VENTRAL HIPPOCAMPUS; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX; ANIMAL-MODEL; HORSERADISH-PEROXIDASE; SCHIZOPHRENIC-PATIENTS; IBOTENIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
B. Pouzet et al., "The effects of hippocampal and fimbria-fornix lesions on prepulse inhibition", BEHAV NEURO, 113(5), 1999, pp. 968-981

Abstract

The present experiments tested the effects of conventional (dorsal aspiration and electrolytic) and excitotoxic (N-methyl-D-aspartate [NMDA]) hippocampal lesions and fimbria-fornix (FF) transection on prepulse inhibition (PPI) of startle response and on open-field activity. Activity was increased by FF transection and by conventional but not excitotoxic hippocampal lesions; complete NMDA lesion increased amphetamine-induced activity. Whereas dorsal hippocampal aspiration lesion disrupted PPI, the phenomenon was not affected by dorsal hippocampal electrolytic lesion, partial or complete excitotoxic (NMDA) hippocampal lesions, or complete FF transection, which interrupted the cholinergic input to the hippocampus as well as the hippocampal-subicular input to the nucleus accumbens. Systemic apomorphine disrupted PPI in both FF-transected rats and their controls. It is suggested that the hippocampus is essential for PPI disruption rather than for PPI expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:44:34