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Titolo:
Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations
Autore:
Nader, K; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 5, volume: 113, anno: 1999,
pagine: 891 - 901
SICI:
0735-7044(199910)113:5<891:IOTMDP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; VENTRAL TEGMENTAL AREA; FREELY BEHAVING RAT; LASTING POTENTIATION; ANTAGONIST SCH-23390; NEUROTOXIC LESIONS; CONTEXTUAL STIMULI; NUCLEUS-ACCUMBENS; AMYGDALA; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, K NYU, Ctr Neural Sci, 4 Washington Pl,Room 1105, New York, NY 10003 USA NYU 4 Washington Pl,Room 1105 New York NY USA 10003 NY 10003 USA
Citazione:
K. Nader e J.E. LeDoux, "Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations", BEHAV NEURO, 113(5), 1999, pp. 891-901

Abstract

Previous findings have demonstrated that systemic dopaminergic manipulations impair the retrieval of Pavlovian conditioned fear. A second-order fear-conditioning paradigm was used to test whether the dopaminergic projection from the ventral tegmental area (VTA) to the lateral and basal amygdala (LBA) can affect conditioned fear. Phase I entailed conditioned stimulus-unconditioned stimulus (CSI-US) pairings. In Phase 2, drugs were infused in either the LBA or VTA prior to pairings of CS2 (a second cue) with CS1. In Phase 3, freezing behavior elicited by CS2 was tested without drugs. Infusions of the D2 agonist quinpirole into the VTA or of the D1 antagonist SCH 23390into the LBA caused a decrease in freezing to CS2. Both manipulations decrease DI receptor activation in the LBA. Infusions of the D1 agonist SKF 38393 into the LBA had no effect. This pattern of results is consistent with the hypothesis that the VTA-LBA dopaminergic projection modulates the retrieval of an association between a CS and footshock US.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 16:59:43