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Titolo:
Low density lipoprotein (LDL) binding affinity for the LDL receptor in hyperlipoproteinemia
Autore:
Toyota, Y; Yamamura, T; Miyake, Y; Yamamoto, A;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Dept Etiol & Pathophysiol, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 147, anno: 1999,
pagine: 77 - 86
SICI:
0021-9150(199911)147:1<77:LDL(BA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTERYL ESTER TRANSFER; CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; PLASMA TRIGLYCERIDE CONCENTRATION; FAMILIAL COMBINED HYPERLIPIDEMIA; HUMAN-SKIN FIBROBLASTS; TRANSFER PROTEIN; PARTICLE-SIZE; APOLIPOPROTEIN-B; RISK-FACTORS;
Keywords:
low density lipoprotein (LDL); low density lipoprotein receptor; hyperlipoproteinemia; hypertriglyceridemia; small, dense low density lipoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamura, T Natl Cardiovasc Ctr, Res Inst, Dept Etiol & Pathophysiol, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishiro Dai Suita Osaka Japan 5658565
Citazione:
Y. Toyota et al., "Low density lipoprotein (LDL) binding affinity for the LDL receptor in hyperlipoproteinemia", ATHEROSCLER, 147(1), 1999, pp. 77-86

Abstract

We measured the binding affinity of low density lipoprotein (LDL) for the LDL receptor in patients with various types of hyperlipoproteinemia and investigated the effects of LDL lipid composition and particle size on receptor affinity. LDL (1.019 < d <1.063) was isolated by sequential ultracentrifugation from the serum of normolipidemic controls and patients with hyperlipoproteinemia. Patients with type IIa hyperlipoproteinemia had LDL with a similar receptor affinity to that of normal LDL. However, patients with hypertriglyceridemia (type IIb and type IV hyperlipoproteinemia) had LDL with a low receptor affinity, and the degree of the reduction in affinity paralleled the severity of the hypertriglyceridemia. The LDL of hypertriglyceridemic patients was rich in protein and triglycerides, had a low content of cholesterol and phospholipids, and was smaller than normal, thus resembling theatherogenic lipoprotein known as small, dense LDL. These abnormalities were observed even in patients with mild hypertriglyceridemia regardless of their serum cholesterol levels. The degree of alteration in LDL lipid composition and particle size was strongly associated with the reduction of LDL receptor affinity. We also examined the effects of two lipid-lowering agents (bezafibrate and probucol) on the characteristics of LDL. LDL receptor affinity was only improved when the lipid composition and particle size were normalized by drug therapy. Although it has been reported that decreased cholesteryl ester transfer protein (CETP) activity results i.n the formation ofsmall LDL, plasma CETP activity was normal in the hyperlipoproteinemic patients and the normalization of LDL characteristics by drug therapy was not accompanied by an increase of CETP activity. Our results suggested that an abnormal lipid composition and/or small particle size might cause a decrease in the receptor affinity of LDL. These structural and functional abnormalities were reversed by drug therapy, underlining the importance of treatinghypertriglyceridemia for the prevention of atherosclerosis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:02:00