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Titolo:
Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk?
Autore:
Summers, LKM; Samra, JS; Frayn, KN;
Indirizzi:
Radcliffe Infirm, Nuffield Dept Clin Med, Oxford Lipid Metab Grp, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE tab Grp, Oxford OX2 6HE, England
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 147, anno: 1999,
pagine: 11 - 15
SICI:
0021-9150(199911)147:1<11:IPTROB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; DEPENDENT DIABETES-MELLITUS; CORONARY HEART-DISEASE; NITRIC-OXIDE RELEASE; HUMAN ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION; OBESITY; LIPASE; HYPERTRIGLYCERIDEMIA;
Keywords:
postprandial tissue blood flow; obesity; insulin resistance; coronary artery disease; hypertriglyceridaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Summers, LKM St Thomas Hosp, Dept Endocrinol Diabet & Metab Med, London SE1 7EH, England St Thomas Hosp London England SE1 7EH ndon SE1 7EH, England
Citazione:
L.K.M. Summers et al., "Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk?", ATHEROSCLER, 147(1), 1999, pp. 11-15

Abstract

The insulin resistant state is a major risk factor for coronary artery disease. This increased risk is likely to be due to associated lipid and coagulation abnormalities rather than just abnormalities in glucose metabolism or hyperinsulinaemia alone. Exaggerated postprandial lipaemia is a well-recognised associate of insulin resistance and postprandial hypertriglyceridaemia is particularly important in the development of coronary atheroma. It seems likely that insulin is one of the hormonal regulators of adipose tissueand skeletal muscle blood flow. The reduced blood fl ow and blunting of the postprandial rise of peripheral blood flow in insulin resistance may decrease chylomicron-triglyceride delivery to muscle in subjects with insulin resistance. This, in turn, will lead to increased production of atherogenic particles. We propose that impaired postprandial vasodilation, already recognised as a key feature of glucose intolerance, is also the cause of impaired lipid metabolism in insulin resistant subjects and predisposes them to cardiovascular disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:37:28