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Titolo:
Effect of intravenous administration of furosemide on mass-specific maximal oxygen consumption and breathing mechanics in exercising horses
Autore:
Bayly, WM; Slocombe, RF; Schott, HC; Hodgson, DR;
Indirizzi:
Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 lin Sci, Pullman, WA 99164 USA Univ Melbourne, Sch Vet Sci, Werribee, Vic 3030, Australia Univ MelbourneWerribee Vic Australia 3030 Werribee, Vic 3030, Australia
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 11, volume: 60, anno: 1999,
pagine: 1415 - 1422
SICI:
0002-9645(199911)60:11<1415:EOIAOF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY HEMORRHAGE; THOROUGHBRED HORSES; PHYSIOLOGICAL VARIABLES; RACING TIMES; FRUSEMIDE; RACEHORSES; RESPONSES; CAPACITY; EXERTION; SYSTEMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bayly, WM Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman,WA 99164 USA Washington State Univ Pullman WA USA 99164 ullman, WA 99164 USA
Citazione:
W.M. Bayly et al., "Effect of intravenous administration of furosemide on mass-specific maximal oxygen consumption and breathing mechanics in exercising horses", AM J VET RE, 60(11), 1999, pp. 1415-1422

Abstract

Objectives-To determine whether IV administration of furosemide (250 mg) to horses before maximal exercise affected maximal oxygen consumption ((V) over dot O-2 max), breathing mechanics, or gas exchange during exercise. Animals-7 healthy, well-conditioned Thoroughbred horses. Procedures-5 horses initially performed an incremental treadmill exercise test to determine (V) over dot O-2 max 4 hours after IV administration of furosemide (250 mg IV) or placebo (saline [0.9% NaCl] solution). Time to fatigue and distance run were recorded, Ail 7 horses were then used to determine the effects of furosemide on gas exchange acid breathing mechanics at 40, 60, 80, and 100% of (V) over dot O-2 max. Horses were weighed immediatelybefore exercise,Results-Furosemide treatment significantly increased mass-specific (V) over dot O-2 max (5.3%), but absolute (V) over dot O-2 max was not significantly altered, In the 2 parts of the study, body weights were 2.9 and 2.5% higher when horses were given placebo than when they were given furosemide. Time and distance run at speeds greater than or equal to 11.0 m/s were significantly greater following furosemide administration. Furosemide treatment had no effect on breathing mechanics or gas exchange,Conclusions and Clinical Relevance-Previous studies have suggested that prerace administration of furosemide may have a positive effect on performance, Results of this study indicate that this may be attributable, in part, to an increase in mass-specific (V) over dot O-2 max but not to improvementsin breathing mechanics or gas exchange. Most of the increase in mass-specific (V) over dot O-2 max appeared to be attributable to weight loss associated with diuresis induced by furosemide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:16:38