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Titolo:
Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy
Autore:
Schmidt, RE; Dorsey, DA; Beaudet, LN; Plurad, SB; Parvin, CA; Miller, MS;
Indirizzi:
Washington Univ, Sch Med, Dept Pathol, Div Neuropathol, St Louis, MO 63110USA Washington Univ St Louis MO USA 63110 Neuropathol, St Louis, MO 63110USA Washington Univ, Sch Med, Dept Pathol, Div Lab Med, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 Div Lab Med, St Louis, MO 63110 USA Cephalon Inc, W Chester, PA USA Cephalon Inc W Chester PA USACephalon Inc, W Chester, PA USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 155, anno: 1999,
pagine: 1651 - 1660
SICI:
0002-9440(199911)155:5<1651:IGFIRE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC-ISLET TRANSPLANTATION; PERIPHERAL-NERVE REGENERATION; RETROGRADE AXONAL-TRANSPORT; NEUROAXONAL DYSTROPHY; SYMPATHETIC-NERVES; BINDING-PROTEINS; GENE-EXPRESSION; SENSORY NEURONS; MESSENGER-RNA; ADULT-RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, RE Washington Univ, Sch Med, Dept Pathol, Div Neuropathol, 660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave St Louis MO USA 63110 110 USA
Citazione:
R.E. Schmidt et al., "Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy", AM J PATH, 155(5), 1999, pp. 1651-1660

Abstract

Recent studies have suggested a role for neurotrophic substances in the pathogenesis and treatment of diabetic neuropathy. In this study, the effect of insulinlike growth factor I (IGF-I) on diabetic sympathetic autonomic neuropathy was examined in an experimental streptozotocin-induced diabetic rat model. Two months of IGF-I treatment of chronically diabetic rats with established neuroaxonal dystrophy (the neuropathological hallmark of the disease) involving the superior mesenteric ganglion and heal mesenteric nerves resulted in nearly complete normalization of the frequency of neuroaxonal dystrophy in both sites without altering the severity of diabetes. Treatmentwith low-dose insulin (to control for the transient glucose-lowering effects of IGF-I) failed to affect the frequency of ganglionic or mesenteric nerve neuroaxonal dystrophy or the severity of diabetes. The striking improvement in the severity of diabetic autonomic neuropathy shown with IGF-I treatment in these studies and the fidelity of the rat model to findings in diabetic human sympathetic ganglia provide promise for the development of new clinical therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:36:13