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Titolo:
32/67-kD laminin receptor expression in human colonic neoplasia: Elevated transcript levels correlate with the degree of epithelial dysplasia
Autore:
Stallmach, A; Orzechowski, HD; Feldmann, P; Riecken, EO; Zeitz, M; Herbst, H;
Indirizzi:
Univ Saarland, Dept Internal Med 2, Hamburg, Germany Univ Saarland Hamburg Germany nd, Dept Internal Med 2, Hamburg, Germany Free Univ Berlin, Klinikum Benjamin Franklin, Inst Pathol, D-12200 Berlin,Germany Free Univ Berlin Berlin Germany D-12200 t Pathol, D-12200 Berlin,Germany Free Univ Berlin, Klinikum Benjamin Franklin, Dept Med & Pharmacol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 armacol, D-12200 Berlin, Germany Univ Hamburg, Inst Pathol, D-2000 Hamburg, Germany Univ Hamburg Hamburg Germany D-2000 Inst Pathol, D-2000 Hamburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 11, volume: 94, anno: 1999,
pagine: 3341 - 3347
SICI:
0002-9270(199911)94:11<3341:3LREIH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CARCINOMA PROGRESSION; CANCER CELL-LINES; EXTRACELLULAR-MATRIX; TUMOR INVASION; MESSENGER-RNA; OVEREXPRESSION; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Stallmach, A Clin Internal Med 2, D-66421 Homburg, Germany Clin Internal Med 2 Homburg Germany D-66421 omburg, Germany
Citazione:
A. Stallmach et al., "32/67-kD laminin receptor expression in human colonic neoplasia: Elevated transcript levels correlate with the degree of epithelial dysplasia", AM J GASTRO, 94(11), 1999, pp. 3341-3347

Abstract

OBJECTIVE: The 32/67-kD laminin receptor is thought to be involved in tumor cell migration and metastasis formation, and enhanced expression was observed in human colorectal carcinoma. Our objective was to investigate further the expression of the 32/67-kD laminin receptor RNA in human colonic carcinogenesis. METHODS: We obtained sections of human colonic tissues in various stages of malignant transformation and analyzed them by in situ hybridization. RESULTS: Normal colonic mucosa displayed a gradient between crypt base andsurface epithelium with lowest receptor RNA levels in superficial epithelial cells. Increased laminin receptor RNA expression was observed in epithelial cells of adenomas with positive correlation between transcript levels and the degree of epithelial dysplasia. At variance with published results, we did not observe significant differences in 32/67-kD laminin receptor transcripts between adenomas with high-grade dysplasia and invasive adenocarcinoma. However, adenocarcinoma metastases displayed significantly higher laminin receptor RNA levels than high-grade adenomas and primary carcinomas. CONCLUSIONS: We propose a two-step mechanism which controls first, upregulation of laminin receptor RNA before the acquisition of an invasive phenotype in dysplastic epithelial cells, and second, a further upregulation in metastatic cells during the adenoma-carcinoma sequence of the colon. (C) 1999by Am. Coll. of Gastroenterology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:55:22