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Titolo:
Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging
Autore:
Meyerhoff, DJ; Bloomer, C; Schuff, N; Ezekiel, F; Norman, D; Clark, W; Weiner, MW; Fein, G;
Indirizzi:
DVA Med Ctr, MR Unit, San Francisco, CA 94121 USA DVA Med Ctr San Francisco CA USA 94121 Unit, San Francisco, CA 94121 USA Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 4, anno: 1999,
pagine: 405 - 419
SICI:
1355-6215(199910)4:4<405:CMAIAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; BRAIN GLUCOSE-METABOLISM; CHRONIC-ALCOHOLICS; POLYSUBSTANCE ABUSERS; PERFUSION; SPECT; TOMOGRAPHY; VOLUME; USERS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Meyerhoff, DJ DVA Med Ctr, MR Unit, 4150 Clement St,114M, San Francisco, CA 94121 USA DVA Med Ctr 4150 Clement St,114M San Francisco CA USA 94121
Citazione:
D.J. Meyerhoff et al., "Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging", ADDICT BIOL, 4(4), 1999, pp. 405-419

Abstract

Chronic abuse of cocaine or alcohol is associated with structural, neuropathological and cognitive impairments that have been documented extensively. Little is known, however, about neurobiochemical changes in chronic substance abusers. We performed MRI and multi-slice brain proton magnetic resonance spectroscopic imaging (MRSI) to assess neuronal viability (via N-acetylaspartate (NAA)) and white matter metabolite status tit 22 4-months-abstinent individuals dependent oz crack cocaine only and on both crack cocaine andalcohol. Compared to II non-dependent controls we found (1) significantly lower NAA measures in the dorsolateral prefrontal cortex of the combined cocaine-dependent groups; (2) comparable spatial distribution and magnitude of these NAA effects for both cocaine-dependence groups; (3) higher choline-containing metabolites in frontal white matter of individuals dependent on both cocaine and alcohol; (4) absence of brain atrophy in both abstinent cocaine-dependent samples; and (5) partial recovery from prefrontal cortical NAA loss, primarily with abstinence from alcohol. The MRSI findings suggestpreferential neuronal damage to the frontal cortex of both cocaine-dependent samples and gliosis in frontal white matter of individuals dependent on both alcohol and cocaine, conditions that persist for more than 4 months ofabstinence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:59:06