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Titolo:
Polymorphism of dopamine D2 and D4 receptor genes and Slavic-surnamed alcoholic patients
Autore:
Ovchinnikov, IV; Druzina, E; Ovtchinnikova, O; Zagorovskaya, T; Nebarakova, T; Anokhina, IP;
Indirizzi:
Minist Hlth, Inst Gerontol, Moscow, Russia Minist Hlth Moscow RussiaMinist Hlth, Inst Gerontol, Moscow, Russia Russian Acad Med Sci, Genet Identificat Ctr, Moscow, Russia Russian Acad Med Sci Moscow Russia enet Identificat Ctr, Moscow, Russia Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia Russian Acad Med Sci Moscow Russia 109801 Res Ctr, Moscow 109801, Russia Minist Hlth, Res Inst Addict, Moscow, Russia Minist Hlth Moscow RussiaMinist Hlth, Res Inst Addict, Moscow, Russia
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 4, anno: 1999,
pagine: 399 - 404
SICI:
1355-6215(199910)4:4<399:PODDAD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAQI A1 ALLELE; NO ASSOCIATION; NOVELTY SEEKING; DRD2 LOCUS; RFLP; POPULATION; LINKAGE; FREQUENCIES; HAPLOTYPES; SAMPLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ovchinnikov, IV Columbia Univ, Dept Med, Div Mol Med, 622 W 168th St, New York, NY 10032 USA Columbia Univ 622 W 168th St New York NY USA 10032 032 USA
Citazione:
I.V. Ovchinnikov et al., "Polymorphism of dopamine D2 and D4 receptor genes and Slavic-surnamed alcoholic patients", ADDICT BIOL, 4(4), 1999, pp. 399-404

Abstract

The association between alcoholism and the Taq1 "A" and "B" polymorphic alleles at the DRD2 gene and 48-bp tandem repeat in exon 3 of dopamine D4 receptor (DRD4) gene in 42 unrelated Slavic-surnamed patients and 76 normal controls was examined. The frequency of the A I allele was higher in alcoholic patients and in alcoholic patients with a family history of alcoholism than in controls (chi(2) = 3.45, p < 0.001 and chi(2) = 3.97, p < 0.001, respectively. Moreover, the frequency of the A1 allele was higher in alcoholicswith a family history alcoholism? than in alcoholics without a family history (chi(2) = 3.33, p < 0.001). The results of association analysis for both the Taq1 "B" and DRD4 alleles were negative for alcoholics in general, subgroups of alcoholics and normal controls. However; the 7-repeat allele (DRD4*7R) of DRD4 gene occurred at significantly higher frequency in alcoholics with a family history of alcoholism compared with those without a family history (chi(2) = 3. 42, p < 0.01). The results indicate that the A1 alleleof the DRD2 gene is associated with susceptibility to alcoholism in general. The A1 allele, as well as the DRD4*7R allele, is significantly prevalentamong alcoholics with a family history, in comparison with alcoholics without a family history, reflecting different roles of genetic factors in development of alcoholism.

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Documento generato il 07/04/20 alle ore 23:01:38