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Titolo:
Role of the sarcoplasmic reticulum in the modulation of rat cardiac actionpotential by stretch
Autore:
Han, C; Tavi, P; Weckstrom, M;
Indirizzi:
Univ Oulu, Dept Physiol, Div Biophys, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 l, Div Biophys, FIN-90220 Oulu, Finland Univ Oulu, Bioctr, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 v Oulu, Bioctr, FIN-90220 Oulu, Finland Univ Oulu, Dept Phys Sci, Div Biophys, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 i, Div Biophys, FIN-90220 Oulu, Finland
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 2, volume: 167, anno: 1999,
pagine: 111 - 117
SICI:
0001-6772(199910)167:2<111:ROTSRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG VENTRICULAR MYOCYTES; ACTIVATED ION CHANNELS; INTRACELLULAR CALCIUM TRANSIENTS; MECHANICAL STRETCH; MUSCLE LENGTH; CELL LENGTH; HEART; CONTRACTION; MEMBRANE; CA2+;
Keywords:
caffeine; membrane potential; ryanodine; sarcoplasmic reticulum; thapsigargin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Weckstrom, M Univ Oulu, Dept Physiol, Div Biophys, Kajaanintie 52 A, FIN-90220 Oulu, Finland Univ Oulu Kajaanintie 52 A Oulu Finland FIN-90220 u, Finland
Citazione:
C. Han et al., "Role of the sarcoplasmic reticulum in the modulation of rat cardiac actionpotential by stretch", ACT PHYSL S, 167(2), 1999, pp. 111-117

Abstract

We have investigated the role of sarcoplasmic reticulum (SR) in the modulation on rat action potentials by stretch. The action potentials were recorded intracellularly from rat atrial myocytes in an isolated atrial preparation with small, physiological stretch produced by pressure (1-3 mmHg) insidethe atria. The SR function was inhibited by pharmacological interventions,either with ryanodine (100 nmol L-1), thapsigargin (10 nmol L-1) or caffeine (1 mmol L-1). The duration of action potentials was increased by stretchfrom 1 to 3 mmHg. The repolarization indices APD(30%) (P < 0.05), APD(60%)(P < 0.01), and APD(90%) (P < 0.01) were all increased significantly (n = 10). Ryanodine, thapsigargin. and caffeine inhibited this prolongation, or even reversed the effect with repolarization indices APD(30%) (P < 0.05) and APD(60%) (P < 0.05) which decreased in stretch with thapsigargin treatment. As a conclusion, we suggest that the SR and the intracellular calcium balance play an important role in the modulation of the shape of the rat atrial action potential during stretch.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:48:27