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Titolo:
Cystine protects cochlear outer hair cells against glutamate toxicity
Autore:
Sunami, K; Yamane, H; Takayama, M; Nakagawa, T; Konishi, K; Iguchi, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ngol, Abeno Ku, Osaka 5458585, Japan Yodogawa Christian Hosp, Dept Otorhinolaryngol, Osaka, Japan Yodogawa Christian Hosp Osaka Japan Dept Otorhinolaryngol, Osaka, Japan PL Hosp, Dept Otorhinolaryngol, Osaka, Japan PL Hosp Osaka JapanPL Hosp, Dept Otorhinolaryngol, Osaka, Japan
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 6, volume: 119, anno: 1999,
pagine: 671 - 673
SICI:
0001-6489(1999)119:6<671:CPCOHC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE; NOISE; LINE;
Keywords:
antiporter; cystine; glutamate; glutathione;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sunami, K Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, 1-5-7Asahi Machi, Osaka 5458585, Japan Osaka City Univ 1-5-7 Asahi Machi OsakaJapan 5458585 85, Japan
Citazione:
K. Sunami et al., "Cystine protects cochlear outer hair cells against glutamate toxicity", ACT OTO-LAR, 119(6), 1999, pp. 671-673

Abstract

We previously reported that long-term exposure to glutamate (Glu) induced death of cochlear outer hair cells (OHCs). However. the mechanisms of OHC death induced by Glu were unclear. In the central nervous system, Glu is known to interfere with a cystine-Glu antiporter, leading to a decrease in cystine uptake and reducing the intracellular glutathione level. We therefore investigated the effect of cystine supplementation on degeneration of OHCs caused by long-term exposure to Glu. Supplementation of cystine significantly decreased the number of dying OHCs. These findings suggest that a cystine-Glu interaction may be involved in the mechanism of OHC degeneration caused by Glu.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:30:05