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Titolo:
Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m-toluamide (DEET)
Autore:
Schoenig, GP; Osimitz, TG; Gabriel, KL; Hartnagel, R; Gill, MW; Goldenthal, EI;
Indirizzi:
Toxicol Regulatory Serv Inc, Charlottesville, VA 22911 USA Toxicol Regulatory Serv Inc Charlottesville VA USA 22911 le, VA 22911 USA SC Johnson & Son Inc, Racine, WI 53403 USA SC Johnson & Son Inc Racine WIUSA 53403 & Son Inc, Racine, WI 53403 USA ConTox Ltd, Ft Washington, PA 19034 USA ConTox Ltd Ft Washington PA USA 19034 ox Ltd, Ft Washington, PA 19034 USA MPI Res, Mattawan, MI 49071 USA MPI Res Mattawan MI USA 49071MPI Res, Mattawan, MI 49071 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 47, anno: 1999,
pagine: 99 - 109
SICI:
1096-6080(199901)47:1<99:EOTCTA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
N-N-diethyl-m-toluamide (DEET); insect repellent; chronic toxicity; oncogenicity; dog; rat; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Schoenig, GP Toxicol Regulatory Serv Inc, 2345 Hunters Way 3, Charlottesville, VA 22911USA Toxicol Regulatory Serv Inc 2345 Hunters Way 3 Charlottesville VA USA 22911
Citazione:
G.P. Schoenig et al., "Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m-toluamide (DEET)", TOXICOL SCI, 47(1), 1999, pp. 99-109

Abstract

Chronic toxicity and/or oncogenicity studies were conducted in rats, mice,and dogs with the insect repellent DEET. DEET was mixed in the diet and administered to CD(R) rats for two years at concentrations that corresponded to dosage levels of 10, 30 or 100 mg/kg/day for males and 30, 100, or 400 mg/kg/day for females; to CD(R)-1 mice for 18 months at dosage levels of 250, 500, or 1000 mg/kg/day; and to dogs for one year, via gelatin capsules, at dosage levels of 30, 100, or 400 mg/kg/day, In the rodent studies, each group consisted of 60 animals of each sex, and two concurrent independent control groups, each containing 60 animals/sex were included in each study. Each group in the dog study consisted of four male and four female dogs and one control group was included in the study. Treatment-related effects wereobserved at the highest dose level in ail three studies. For rats, the effects included decreases in body weight and food consumption and an increasein serum cholesterol in females only. In mice, the effects observed were decreases in body weight and food consumption in both sexes. The effects observed in dogs included increased incidences of emesis and ptyalism, and levels of transient reduction in hemoglobin and hematocrit, increased alkalinephosphatase (males only), decreased cholesterol, and increased potassium. One male dog in the high-dose group also exhibited ataxia, tremors, abnormal head movements, and/or convulsions on several occasions during the study. The highest no-observed-effect levels (NOELs) for rats, mice and dogs weredetermined to be 100, 500, and 100 mg/kg/day, respectively. No specific target organ toxicity or oncogenicity was observed in any of the studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:17:08