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Titolo:
Exposure of C57BL/6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet
Autore:
Lewis, JG; Graham, DG; Valentine, WM; Morris, RW; Morgan, DL; Sills, RC;
Indirizzi:
Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Vanderbilt Univ, Sch Med, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA Analyt Sci Inc, Durham, NC 27713 USA Analyt Sci Inc Durham NC USA 27713Analyt Sci Inc, Durham, NC 27713 USA NIEHS, Environm Toxicol Program, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709 Program, Res Triangle Pk, NC 27709 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 49, anno: 1999,
pagine: 124 - 132
SICI:
1096-6080(199905)49:1<124:EOCMTC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; HUMAN MONOCYTE-MACROPHAGES; CROSS-LINKING; MORTALITY; SUSCEPTIBILITY; NEUROTOXICITY; MORPHOLOGY; RESISTANCE; STRAINS;
Keywords:
carbon disulfide; atherosclerosis; arterial fatty deposits; foam cells; high fat diet; spectrin; and inhalation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, JG Duke Univ, Med Ctr, Dept Pathol, Box 3712, Durham, NC 27710 USA Duke Univ Box 3712 Durham NC USA 27710 712, Durham, NC 27710 USA
Citazione:
J.G. Lewis et al., "Exposure of C57BL/6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet", TOXICOL SCI, 49(1), 1999, pp. 124-132

Abstract

Even though atherosclerotic cardiovascular disease (ACVD) is the number one cause of death in the United States, the effects of environmental toxicants on this process are less well studied than the effects of chemicals on the second leading cause of death, cancer. There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) have increasedrates of ACVD, and there is conflicting evidence of the atherogenic potential of CS2 from animal studies. Chemical modification, such as oxidation oflow-density lipoproteins (LDL), is tightly associated with increased LDL uptake by macrophages and the development of arterial fatty streaks. CS2 hasbeen previously demonstrated to modify several proteins in vitro includingLDL, and others in vivo through derivatization and covalent cross-linking,To investigate both the capacity of CS2 to induce arterial fatty deposits by itself, and its ability to enhance the rate of fatty deposit formation induced by a western style, high fat diet, groups of 20 female C57BL/6 mice were exposed to 0, 50, 500, or 800 ppm CS2 by inhalation, Half the animals in each group were placed on an atherogenic high fat diet and half on a control diet (NIH-07), Animals were sacrificed after 1, 4, 8, 12, 16, or 20 weeks of exposure, and the rates of fatty deposit formation under the aortic valve leaflets were evaluated. Exposure of mice on the control diet to 500 and 800 ppm CS2 induced a small but significant increase in the rate of fatty deposit formation over non-exposed controls. A more striking result was observed in the animals on the high fat diet, There was marked enhancement of the rate of fatty deposit formation in mice exposed to 500 and 800 ppm over the animals on the high fat diet alone. In addition, there was a small but significant enhancement in mice exposed to 50 ppm over the rate of fatty deposit formation induced by the high fat diet alone, Analysis of erythrocyte spectrin for protein cross-linking revealed a dose-dependent formationof alpha- and beta-heterodimers in animals on both diets, These data demonstrate that CS2 is atherogenic at high concentrations, but more importantly, suggest that, in conjunction with other risk factors, CS2 at relatively low concentrations can enhance atherogenesis.

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Documento generato il 18/02/20 alle ore 11:29:52