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Titolo:
Neural plasticity in the somatosensory system
Autore:
Knecht, S; Ringelstein, EB;
Indirizzi:
Univ Munster, Neurol Klin, D-48129 Munster, Germany Univ Munster MunsterGermany D-48129 urol Klin, D-48129 Munster, Germany
Titolo Testata:
NERVENARZT
fascicolo: 10, volume: 70, anno: 1999,
pagine: 889 - 898
SICI:
0028-2804(199910)70:10<889:NPITSS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
GER
Soggetto:
PHANTOM-LIMB PAIN; MASSIVE CORTICAL REORGANIZATION; MOTOR CORTEX INJURY; ADULT OWL MONKEYS; FUNCTIONAL REORGANIZATION; SPINAL-CORD; AREA 3B; SENSORIMOTOR CORTEX; EVOKED POTENTIALS; COMMON-DRUGS;
Keywords:
neural plasticity; reorganization; somatosensory; phantom; amputation; magnetoencephalography; pain; cortex;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Knecht, S Univ Munster, Neurol Klin, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129 y
Citazione:
S. Knecht e E.B. Ringelstein, "Neural plasticity in the somatosensory system", NERVENARZT, 70(10), 1999, pp. 889-898

Abstract

The mammalian brain is capable of a substantial functional reorganization,manifesting on a cortical somatotopical and on a behavioral level. Possible mechanisms are reviewed based on the work by others and ourselves on somatosensory reorganization in humans. The somatosensory system is characterized by divergent projections from the periphery to the cerebral cortex. Changes in synaptic weights allow for reorganization of sensory processing: On one side, limb amputation will result in a representational "invasion" of the deafferentated cortex from neighboring regions with concomitant perceptual changes. On the other side, sensorimotor training can increase the representational cortical zone of a limb. Plastic changes can be temporary or persistent. Modulating factors like pain and certain drugs seem to induce a permissive state in the cortex resulting in enhanced reorganization. Thus, specific physical training combined with pharmacoceutical modulation holds promise to improve functional recovery after brain lesions.

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Documento generato il 20/01/21 alle ore 01:48:27