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Titolo:
Seminal vesicle production and secretion of growth hormone into seminal fluid
Autore:
Dyck, MK; Gagne, D; Ouellet, M; Senechal, JF; Belanger, E; Lacroix, D; Sirard, MA; Pothier, F;
Indirizzi:
Univ Laval, Ctr Rech Biol Reprod, Dept Anim Sci, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 Anim Sci, St Foy, PQ G1K 7P4, Canada
Titolo Testata:
NATURE BIOTECHNOLOGY
fascicolo: 11, volume: 17, anno: 1999,
pagine: 1087 - 1090
SICI:
1087-0156(199911)17:11<1087:SVPASO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEINS; TRANSGENE EXPRESSION; REGULATED EXPRESSION; PROTEASE INHIBITOR; ACROSIN INHIBITOR; BOAR SPERMATOZOA; HEPARIN-BINDING; MAMMARY-GLAND; PLASMA; PROMOTER;
Keywords:
transgenic mice; agriculture; genetic engineering; bioreactor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Pothier, F Univ Laval, Ctr Rech Biol Reprod, Dept Anim Sci, Pavillon Paul Comtois, StFoy, PQ G1K 7P4, Canada Univ Laval Pavillon Paul Comtois St Foy PQ Canada G1K 7P4 anada
Citazione:
M.K. Dyck et al., "Seminal vesicle production and secretion of growth hormone into seminal fluid", NAT BIOTECH, 17(11), 1999, pp. 1087-1090

Abstract

Production of foreign proteins in the tissues of transgenic animals represents an efficient and economical method of producing therapeutic and pharmaceutical proteins. In this study, we demonstrate that the mouse P12 gene promoter specific to the male accessory sex gland can be used to generate transgenic mice that express human growth hormone (hGH) in their seminal vesicle epithelium. The hGH is secreted into the ejaculated seminal fluids with the seminal vesicle lumen contents containing concentrations of up to 0.5 mg/ml. As semen is a body fluid that can be collected easily on a continuousbasis, the production of transgenic animals expressing pharmaceutical proteins into their seminal fluid could prove to be a viable alternative to useof the mammary gland as a bioreactor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:10:33