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Titolo:
The role of dopamine in the nucleus accumbens in analgesia
Autore:
Altier, N; Stewart, J;
Indirizzi:
Concordia Univ, Ctr Studies Behav Neurobiol, Dept Psychol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
LIFE SCIENCES
fascicolo: 22, volume: 65, anno: 1999,
pagine: 2269 - 2287
SICI:
0024-3205(19991022)65:22<2269:TRODIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; INCREASE EXTRACELLULAR DOPAMINE; CONDITIONED PLACE PREFERENCE; INDUCED LOCOMOTOR-ACTIVITY; STRESS-INDUCED ACTIVATION; SUBSTANCE-P INFUSION; DIRECT SPINAL ACTION; 3 PAIN TESTS; FORMALIN TEST;
Keywords:
nucleus accumbens; dopamine; analgesia; pain; ventral tegmental area; midbrain dopamine systems; morphine; amphetamine; substance P;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, J Concordia Univ, Ctr Studies Behav Neurobiol, Dept Psychol, 1455Maisonneuve Blvd W, Montreal, PQ H3G 1M8, Canada Concordia Univ 1455 Maisonneuve Blvd W Montreal PQ Canada H3G 1M8
Citazione:
N. Altier e J. Stewart, "The role of dopamine in the nucleus accumbens in analgesia", LIFE SCI, 65(22), 1999, pp. 2269-2287

Abstract

Opioid and psychostimulant drugs have long been used for the relief of chronic pain in the clinical situation. Animal studies confirm that these drugs alleviate persistent or tonic pain. Little is known, however, about the neural systems underlying the suppression of tonic pain except that they aredifferent from those mediating the suppression of phasic (i.e., sharp and short-lasting) pain. Although spinal and brainstem-descending pain suppression mechanisms play a role in mediating the inhibition of tonic pain, it appears that this response is additionally mediated by the activation of mechanisms lying rostral to the brainstem. Recent studies suggest that the activation of mesolimbic dopamine (DA) neurons, arising from the cell bodies ofthe ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAcc), plays an important role in mediating the suppression of tonic pain. Other studies suggest that this pain-suppression system involving the activation of mesolimbic DA neurons is naturally triggered by exposure to stress, through the endogenous release of opioids and substance P (SP) in the midbrain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:04:07