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Titolo:
Specific modulatory effect of arachidonic acid on human red blood cell oxalate transport: Clinical implications in calcium oxalate nephrolithiasis
Autore:
Baggio, B; Priante, G; Brunati, AM; Clari, G; Bordin, L;
Indirizzi:
Univ Padua, Dept Med Surg Sci, Padua, Italy Univ Padua Padua ItalyUniv Padua, Dept Med Surg Sci, Padua, Italy Univ Padua, Dept Biol Chem, Padua, Italy Univ Padua Padua ItalyUniv Padua, Dept Biol Chem, Padua, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
, volume: 10, anno: 1999, supplemento:, 14
pagine: S381 - S384
SICI:
1046-6673(199911)10:<S381:SMEOAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; FATTY-ACIDS; HUMAN-ERYTHROCYTES; ANION TRANSPORT; PHOSPHORYLATION; CHANNELS; PERMEABILITY; BAND-3; FLUX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Baggio, B Policlin Univ, Dipartimento Sci Med & Chirurg, Cattedra Nefrol, 4 Piano,Via Giustiniani 2, I-35120 Padua, Italy Policlin Univ 4 Piano,Via Giustiniani 2 Padua Italy I-35120 aly
Citazione:
B. Baggio et al., "Specific modulatory effect of arachidonic acid on human red blood cell oxalate transport: Clinical implications in calcium oxalate nephrolithiasis", J AM S NEPH, 10, 1999, pp. S381-S384

Abstract

Greater arachidonic acid (AA) contents, which were correlated with erythrocyte transmembrane oxalate (Ox) transport, were observed in plasma and erythrocyte membrane phospholipids of patients with idiopathic calcium renal stones, suggesting a link between membrane phospholipid fatty acid composition and cellular Ox transport. To confirm this hypothesis, the effects of exogenous red blood cell incorporation of three different fatty acids (i.e., oleic acid, AA, and eicosapentaenoic acid) on Ox transport and the phosphorylation status of band 3 protein, which has been shown to mediate red blood cell Ox flux, were investigated. Preincubation of erythrocytes with AA induce: a dose-dependent increase in the phosphorylation level of band 3 protein and an increase in transmembrane Ox self-exchange. In contrast, inhibitory effects on both parameters were observed after the incorporation of oleicand eicosapentaenoic acids. These data, together with previous observations of dietary effects on erythrocyte Ox transport and urinary Ox excretion, indicate that genetic and/or nutritional changes in membrane phospholipid fatty acid composition play a crucial role in modulating cellular Ox transport in idiopathic calcium Ox nephrolithiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:48:34